Vascular Endothelial Growth Factor C and D Signaling Pathways as Potential Targets for the Treatment of Neovascular Age-Related Macular Degeneration: A Narrative Review.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2024-07-01 Epub Date: 2024-06-01 DOI:10.1007/s40123-024-00973-4

Ian M Leitch, Michael Gerometta, David Eichenbaum, Robert P Finger, Nathan C Steinle, Megan E Baldwin

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引用次数: 0

Abstract

The development of treatments targeting the vascular endothelial growth factor (VEGF) signaling pathways have traditionally been firstly investigated in oncology and then advanced into retinal disease indications. Members of the VEGF family of endogenous ligands and their respective receptors play a central role in vasculogenesis and angiogenesis during both development and physiological homeostasis. They can also play a pathogenic role in cancer and retinal diseases. Therapeutic approaches have mostly focused on targeting VEGF-A signaling; however, research has shown that VEGF-C and VEGF-D signaling pathways are also important to the disease pathogenesis of tumors and retinal diseases. This review highlights the important therapeutic advances and the remaining unmet need for improved therapies targeting additional mechanisms beyond VEGF-A. Additionally, it provides an overview of alternative VEGF-C and VEGF-D signaling involvement in both health and disease, highlighting their key contributions in the multifactorial pathophysiology of retinal disease including neovascular age-related macular degeneration (nAMD). Strategies for targeting VEGF-C/-D signaling pathways will also be reviewed, with an emphasis on agents currently being developed for the treatment of nAMD.

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血管内皮生长因子 C 和 D 信号通路是治疗新生血管性老年黄斑变性的潜在靶点：叙述性综述。

以血管内皮生长因子（VEGF）信号通路为靶点的治疗方法的开发历来首先在肿瘤学领域进行研究，然后推进到视网膜疾病适应症领域。内源性配体的血管内皮生长因子家族成员及其各自的受体在发育和生理平衡过程中的血管生成和血管形成中发挥着核心作用。它们还可在癌症和视网膜疾病中发挥致病作用。治疗方法主要集中在针对血管内皮生长因子-A 信号传导；然而，研究表明血管内皮生长因子-C 和血管内皮生长因子-D 信号传导途径对肿瘤和视网膜疾病的发病机制也很重要。本综述重点介绍了重要的治疗进展，以及针对 VEGF-A 以外的其他机制的改良疗法仍未满足的需求。此外，它还概述了 VEGF-C 和 VEGF-D 信号在健康和疾病中的替代参与，强调了它们在视网膜疾病（包括新生血管性老年黄斑变性（nAMD））的多因素病理生理学中的关键作用。此外，还将综述针对 VEGF-C/-D 信号通路的策略，重点介绍目前正在开发的用于治疗 nAMD 的药物。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. 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