A novel loop-structure-based bispecific CAR that targets CD19 and CD22 with enhanced therapeutic efficacy against B-cell malignances.

IF 13.6 1区生物学 Q1 CELL BIOLOGY

Protein & Cell Pub Date : 2024-06-01 DOI:10.1093/procel/pwae034

Lijun Zhao, Shuhong Li, Xiaoyi Wei, Xuexiu Qi, Qiaoru Guo, Licai Shi, Ji-Shuai Zhang, Jun Li, Ze-Lin Liu, Zhi Guo, Hongyu Zhang, Jia Feng, Yuanyuan Shi, Suping Zhang, Yu J Cao

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基于环路结构的新型双特异性 CAR，靶向 CD19 和 CD22，提高了对 B 细胞恶性肿瘤的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein & Cell CELL BIOLOGY-

CiteScore

24.00

自引率

0.90%

发文量

1029

审稿时长

6-12 weeks

期刊介绍： Protein & Cell is a monthly, peer-reviewed, open-access journal focusing on multidisciplinary aspects of biology and biomedicine, with a primary emphasis on protein and cell research. It publishes original research articles, reviews, and commentaries across various fields including biochemistry, biophysics, cell biology, genetics, immunology, microbiology, molecular biology, neuroscience, oncology, protein science, structural biology, and translational medicine. The journal also features content on research policies, funding trends in China, and serves as a platform for academic exchange among life science researchers.