Ganopyrone A, a highly rearranged lanostane triterpenoid with antimalarial activity from artificially cultivated fruiting bodies of Ganoderma colossus

IF 3.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2024-05-31 DOI:10.1016/j.phytochem.2024.114168

Rachada Chanphen , Thapanee Pruksatrakul , Wilunda Choowong , Rattaket Choeyklin , Panida Surawatanawong , Masahiko Isaka

引用次数: 0

Abstract

Three previously undescribed highly modified lanostane triterpenoids, ganopyrone A, ganocolossusin I, and ganodermalactone Y, were isolated from the artificially cultivated fruiting bodies of the basidiomycete Ganoderma colossus TBRC-BCC 17711. Ganopyrone A possesses an unprecedented polycyclic carbon skeleton with an α-pyrone ring and C-18/C-23 bond. It showed antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with an IC₅₀ value of 7.8 μM (positive control: dihydroartemisinin, IC₅₀ 1.4 nM), while its cytotoxicity (Vero cells) was much weaker (IC₅₀ 103 μM).

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从人工培植的巨灵芝子实体中提取的具有抗疟活性的高度重排羊角甾烷三萜类化合物--Ganopyrone A。

研究人员从人工培育的巨灵芝 TBRC-BCC 17711 子实体中分离出了三种以前未曾描述过的高度修饰的羊角甾烷三萜类化合物，即甘露内酯 A、甘露苔素 I 和甘露内酯 Y。灵芝内酯 A 具有前所未有的多环碳骨架，带有一个 α-吡酮环和 C-18/C-23 键。它对恶性疟原虫 K1（耐多药菌株）具有抗疟活性，IC50 值为 7.8 μM（阳性对照：双氢青蒿素，IC50 1.4 nM），而其细胞毒性（Vero 细胞）要弱得多（IC50 103 μM）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.