Might procalcitonin help predict imported falciparum malaria in children?

IF 6.3 3区医学 Q1 INFECTIOUS DISEASES

Travel Medicine and Infectious Disease Pub Date : 2024-05-29 DOI:10.1016/j.tmaid.2024.102731

Alexandra Tielli , Rachidou Ouorou , Lauren Pull , Karamo Souare , Olivier Bouchaud , Laurent Brutus , Frédérick Gay , Jean-Yves Siriez

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引用次数: 0

Abstract

Background

Procalcitonin (PCT) has been proposed as a marker for malaria severity in adults, with a threshold of 10 ng/ml for severe falciparum disease. Whether PCT is useful in children is debated.

Patients & methods

A retrospective case-control study was conducted to compare initial PCT levels in children with uncomplicated malaria and a control group, and between children with uncomplicated and severe malaria.

Results

Results showed significantly higher PCT levels in malaria cases compared to the control group and in malaria severe cases compared to uncomplicated cases. A Receiving Operator Characteristic curve established a PCT threshold of 0.65 ng/ml with a negative predictive value of 98.8 % based on a prevalence of 10 %. Analyzing the pooled results of five studies suggested a threshold of 6.17 ng/ml for differentiating uncomplicated and severe malaria.

Conclusion

PCT might be a useful tool to help rule out malaria and predict potential disease severity in returning travelers.

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降钙素原能否帮助预测儿童的输入性恶性疟原虫疟疾？

背景：降钙素原（PCT）被认为是成人疟疾严重程度的标志物，严重恶性疟原虫疾病的阈值为 10 纳克/毫升。PCT对儿童是否有用还存在争议：我们进行了一项回顾性病例对照研究，以比较无并发症疟疾患儿和对照组以及无并发症疟疾患儿和重症疟疾患儿的初始 PCT 水平：结果显示，疟疾病例的 PCT 水平明显高于对照组，疟疾重症病例的 PCT 水平明显高于无并发症病例。根据受检者特征曲线确定的 PCT 临界值为 0.65 纳克/毫升，根据 10% 的发病率计算，其阴性预测值为 98.8%。分析五项研究的汇总结果表明，区分无并发症和重症疟疾的阈值为 6.17 纳克/毫升：PCT可能是一种有用的工具，有助于排除疟疾并预测回国旅行者的潜在疾病严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Travel Medicine and Infectious Disease PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECTIOUS DISEASES

CiteScore

19.40

自引率

1.70%

发文量

211

审稿时长

49 days

期刊介绍： Travel Medicine and Infectious Disease Publication Scope: Publishes original papers, reviews, and consensus papers Primary theme: infectious disease in the context of travel medicine Focus Areas: Epidemiology and surveillance of travel-related illness Prevention and treatment of travel-associated infections Malaria prevention and treatment Travellers' diarrhoea Infections associated with mass gatherings Migration-related infections Vaccines and vaccine-preventable disease Global policy/regulations for disease prevention and control Practical clinical issues for travel and tropical medicine practitioners Coverage: Addresses areas of controversy and debate in travel medicine Aims to inform guidelines and policy pertinent to travel medicine and the prevention of infectious disease Publication Features: Offers a fast peer-review process Provides early online publication of accepted manuscripts Aims to publish cutting-edge papers