Reduced oxygen extraction fraction in deep cerebral veins associated with cognitive impairment in multiple sclerosis.

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Journal of Cerebral Blood Flow and Metabolism Pub Date : 2024-08-01 Epub Date: 2024-05-31 DOI:10.1177/0271678X241259551

Hasan Sawan, Chenyang Li, Sagar Buch, Evanthia Bernitsas, E Mark Haacke, Yulin Ge, Yongsheng Chen

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Abstract

Studying the relationship between cerebral oxygen utilization and cognitive impairment is essential to understanding neuronal functional changes in the disease progression of multiple sclerosis (MS). This study explores the potential of using venous susceptibility in internal cerebral veins (ICVs) as an imaging biomarker for cognitive impairment in relapsing-remitting MS (RRMS) patients. Quantitative susceptibility mapping derived from fully flow-compensated MRI phase data was employed to directly measure venous blood oxygen saturation levels (S_vO₂) in the ICVs. Results revealed a significant reduction in the susceptibility of ICVs (212.4 ± 30.8 ppb vs 239.4 ± 25.9 ppb) and a significant increase of S_vO₂ (74.5 ± 1.89% vs 72.4 ± 2.23%) in patients with RRMS compared with age- and sex-matched healthy controls. Both the susceptibility of ICVs (r = 0.508, p = 0.031) and the S_vO₂ (r = -0.498, p = 0.036) exhibited a moderate correlation with cognitive decline in these patients assessed by the Paced Auditory Serial Addition Test, while no significant correlation was observed with clinical disability measured by the Expanded Disability Status Scale. The findings suggest that venous susceptibility in ICVs has the potential to serve as a specific indicator of oxygen metabolism and cognitive function in RRMS. .

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多发性硬化症患者脑深部静脉氧气萃取率降低与认知障碍有关。

研究脑氧利用率与认知障碍之间的关系对于了解多发性硬化症（MS）疾病进展过程中神经元的功能变化至关重要。本研究探讨了利用大脑内静脉（ICV）的静脉易感性作为复发缓解型多发性硬化症（RRMS）患者认知障碍的成像生物标志物的潜力。利用完全血流补偿磁共振成像相位数据得出的定量易感性图谱直接测量了ICV中静脉血氧饱和度（SvO2）水平。结果显示，与年龄和性别匹配的健康对照组相比，RRMS 患者 ICV 的易感性明显降低（212.4 ± 30.8 ppb vs 239.4 ± 25.9 ppb），SvO2 明显升高（74.5 ± 1.89% vs 72.4 ± 2.23%）。ICV 的易感性（r = 0.508，p = 0.031）和 SvO2（r = -0.498，p = 0.036）与步调听觉连续加法测试（Paced Auditory Serial Addition Test）评估的这些患者的认知能力下降呈中度相关，而与扩展残疾状况量表（Expanded Disability Status Scale）测量的临床残疾无明显相关。研究结果表明，ICV 中的静脉易感性有可能成为 RRMS 患者氧代谢和认知功能的特定指标。.

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来源期刊

Journal of Cerebral Blood Flow and Metabolism 医学-内分泌学与代谢

CiteScore

12.00

自引率

4.80%

发文量

300

审稿时长

3 months

期刊介绍： JCBFM is the official journal of the International Society for Cerebral Blood Flow & Metabolism, which is committed to publishing high quality, independently peer-reviewed research and review material. JCBFM stands at the interface between basic and clinical neurovascular research, and features timely and relevant research highlighting experimental, theoretical, and clinical aspects of brain circulation, metabolism and imaging. The journal is relevant to any physician or scientist with an interest in brain function, cerebrovascular disease, cerebral vascular regulation and brain metabolism, including neurologists, neurochemists, physiologists, pharmacologists, anesthesiologists, neuroradiologists, neurosurgeons, neuropathologists and neuroscientists.