The chemical synthesis and antiviral properties of an acyclovir-phospholipid conjugate.

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry Pub Date : 1985-01-01 DOI:10.3891/acta.chem.scand.39b-0047

C J Welch, A Larsson, A C Ericson, B Oberg, R Datema, J Chattopadhyaya

引用次数: 27

Abstract

The synthesis of acyclovir-phospholipid conjugate (2) is reported through an unambiguous one-step preparation of L-alpha-dimyristoyl phosphatidic acid triethylammonium salt (5). The biological activity of 2 as an antiviral drug has also been investigated.

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无环鸟苷-磷脂缀合物的化学合成及其抗病毒特性。

无环鸟苷-磷脂缀合物(2)的合成是通过l - α -二肉豆醇磷脂酸三乙基铵盐一步合成的(5)。2作为抗病毒药物的生物活性也被研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry

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