How Mcm10 converts the pre-replication complex into two diverging DNA forks

IF 12.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature Structural & Molecular Biology Pub Date : 2024-05-31 DOI:10.1038/s41594-024-01333-3

引用次数: 0

Abstract

Cryo-electron microscopy (cryo-EM) imaging of DNA replication origin activation explains the role of Mcm10, a minichromosome maintenance (MCM) protein homolog, during initiation. Mcm10 acts as a wedge to split the two MCM hexamers of the activated replicative helicase. Diverging replication forks are then established, with changes in the MCM hexamers that promote the topological separation of two DNA strands.

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Mcm10 如何将复制前复合物转化为两个不同的 DNA 叉

DNA复制源激活的低温电子显微镜（cryo-EM）成像解释了微型染色体维护（MCM）蛋白同源物Mcm10在启动过程中的作用。Mcm10 充当楔子，将激活的复制螺旋酶的两个 MCM 六聚体分开。然后，随着 MCM 六聚体的变化，促进两条 DNA 链拓扑分离的分歧复制叉就建立起来了。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Structural & Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-BIOPHYSICS

CiteScore

22.00

自引率

1.80%

发文量

160

审稿时长

3-8 weeks

期刊介绍： Nature Structural & Molecular Biology is a comprehensive platform that combines structural and molecular research. Our journal focuses on exploring the functional and mechanistic aspects of biological processes, emphasizing how molecular components collaborate to achieve a particular function. While structural data can shed light on these insights, our publication does not require them as a prerequisite.