Small extracellular vesicles are rejuvenating factors in young blood

Abstract

Small extracellular vesicles (sEVs) derived from the blood of young mice are shown to have the potential to extend lifespan and rejuvenate physiological functions in aged mice. Mechanistically, microRNA (miRNA) cargoes within these sEVs alleviated age-related dysfunction by promoting the expression of PGC1α and enhancing mitochondrial energy metabolism.