Active biointegrated living electronics for managing inflammation

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2024-05-30 DOI:10.1126/science.adl1102

Jiuyun Shi, Saehyun Kim, Pengju Li, Fuying Dong, Chuanwang Yang, Bryan Nam, Chi Han, Ethan Eig, Lewis L. Shi, Simiao Niu, Jiping Yue, Bozhi Tian

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引用次数: 0

Abstract

Seamless interfaces between electronic devices and biological tissues stand to revolutionize disease diagnosis and treatment. However, biological and biomechanical disparities between synthetic materials and living tissues present challenges at bioelectrical signal transduction interfaces. We introduce the active biointegrated living electronics (ABLE) platform, encompassing capabilities across the biogenic, biomechanical, and bioelectrical properties simultaneously. The living biointerface, comprising a bioelectronics layout and a Staphylococcus epidermidis–laden hydrogel composite, enables multimodal signal transduction at the microbial-mammalian nexus. The extracellular components of the living hydrogels, prepared through thermal release of naturally occurring amylose polymer chains, are viscoelastic, capable of sustaining the bacteria with high viability. Through electrophysiological recordings and wireless probing of skin electrical impedance, body temperature, and humidity, ABLE monitors microbial-driven intervention in psoriasis.

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用于控制炎症的活性生物集成活电子器件。

电子设备与生物组织之间的无缝接口将彻底改变疾病诊断和治疗。然而，合成材料与活体组织之间的生物和生物力学差异给生物电信号传导界面带来了挑战。我们引入了有源生物集成活电子器件（ABLE）平台，该平台同时具备生物源、生物力学和生物电学特性。活体生物界面由生物电子布局和含有表皮葡萄球菌的水凝胶复合材料组成，可在微生物与哺乳动物之间实现多模式信号传导。活水凝胶的细胞外成分是通过热释放天然淀粉聚合物链制备的，具有粘弹性，能够维持细菌的高存活率。通过电生理记录和对皮肤电阻抗、体温和湿度的无线探测，ABLE 监测了微生物对牛皮癣的干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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