{"title":"Systematic exploration of network pharmacology, <i>in silico</i> modeling and pharmacokinetic profiling for vitamin E in polycystic ovarian syndrome.","authors":"Rukaiah Fatma Begum, Sumithra Mohan","doi":"10.2144/fsoa-2023-0245","DOIUrl":null,"url":null,"abstract":"<p><p><b>Aim:</b> This study seeks to explore the possibility of using vitamin E to alleviate the symptoms of polycystic ovarian syndrome (PCOS). <b>Methods:</b> Various computational methods were employed, including network pharmacology utilizing a compound-target-pathway approach, Swiss ADME, OSIRIS<sup>®</sup> property explorer, pkCSM, PASS online web resource and MOLINSPIRATION<sup>®</sup> software. In addition, <i>in silico</i> analysis of vitamin E was performed with ten receptors. <b>Results & discussion:</b> Our findings highlight the diverse potential of vitamin E in alleviating PCOS. The observed influence on hormones is in line with existing PCOS theories regarding cyst development, further enhancing the therapeutic promise of vitamin E. <b>Conclusion:</b> In conclusion, our computational analysis indicates that vitamin E shows potential as a therapeutic agent for alleviating PCOS in adolescents.</p>","PeriodicalId":12568,"journal":{"name":"Future Science OA","volume":"10 1","pages":"FSO952"},"PeriodicalIF":2.4000,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11137767/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future Science OA","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2144/fsoa-2023-0245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Aim: This study seeks to explore the possibility of using vitamin E to alleviate the symptoms of polycystic ovarian syndrome (PCOS). Methods: Various computational methods were employed, including network pharmacology utilizing a compound-target-pathway approach, Swiss ADME, OSIRIS® property explorer, pkCSM, PASS online web resource and MOLINSPIRATION® software. In addition, in silico analysis of vitamin E was performed with ten receptors. Results & discussion: Our findings highlight the diverse potential of vitamin E in alleviating PCOS. The observed influence on hormones is in line with existing PCOS theories regarding cyst development, further enhancing the therapeutic promise of vitamin E. Conclusion: In conclusion, our computational analysis indicates that vitamin E shows potential as a therapeutic agent for alleviating PCOS in adolescents.
目的：本研究旨在探讨使用维生素 E 缓解多囊卵巢综合征（PCOS）症状的可能性。研究方法：采用了多种计算方法，包括利用化合物-目标-途径方法的网络药理学、Swiss ADME、OSIRIS® Property explorer、pkCSM、PASS 在线网络资源和 MOLINSPIRATION® 软件。此外，还利用十种受体对维生素 E 进行了硅学分析。结果与讨论我们的研究结果凸显了维生素 E 在缓解多囊卵巢综合症方面的多种潜力。观察到的对激素的影响与现有的多囊卵巢综合症关于囊肿发展的理论相一致，进一步增强了维生素 E 的治疗前景：总之，我们的计算分析表明，维生素 E 具有缓解青少年多囊卵巢综合症的治疗潜力。
期刊介绍：
Future Science OA is an online, open access, peer-reviewed title from the Future Science Group. The journal covers research and discussion related to advances in biotechnology, medicine and health. The journal embraces the importance of publishing all good-quality research with the potential to further the progress of research in these fields. All original research articles will be considered that are within the journal''s scope, and have been conducted with scientific rigour and research integrity. The journal also features review articles, editorials and perspectives, providing readers with a leading source of commentary and analysis. Submissions of the following article types will be considered: -Research articles -Preliminary communications -Short communications -Methodologies -Trial design articles -Trial results (including early-phase and negative studies) -Reviews -Perspectives -Commentaries
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