Coronary calcified nodules versus nonnodular coronary calcifications: a systematic review and meta-analysis.

IF 2.9 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Medicine Pub Date : 2024-06-01 Epub Date: 2024-04-26 DOI:10.2459/JCM.0000000000001625

F Oliveri, M J H Van Oort, I Al Amri, B O Bingen, F Van der Kley, J W Jukema, A Jurado-Roman, J Montero Cabezas

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引用次数: 0

Abstract

Background: Percutaneous coronary intervention (PCI) on severely calcified coronary lesions is challenging. Coronary calcified nodule (CN) refers to an eccentric and protruding coronary calcification associated with plaque vulnerability and adverse clinical events. This study aims to conduct an extensive review of CNs, focusing on its prognostic impact in comparison with nonnodular coronary calcification (N-CN).

Method: A systematic literature review on PubMed, MEDLINE, and EMBASE databases was conducted for relevant articles. Observational studies or randomized controlled trials comparing CNs and N-CNs were included.

Results: Five studies comparing CNs and N-CNs were pertinent for inclusion. The total number of individuals across these studies was 1456. There were no significant differences in the baseline demographic, clinical, and angiographic data between the CN and N-CN groups. Intracoronary imaging was always utilized. At follow-up, CNs were associated with significantly increased, target vessel revascularization [odds ratio (OR) 2.16; 95% confidence interval (CI): 1.39-3.36, P-value < 0.01, I2 = 0%] and stent thrombosis (OR 9.29; 95% CI: 1.67-51.79, P-value = 0.01, I2 = 0%) compared with N-CN. A trend for greater cardiac death was also assessed in the CN group (OR 1.75; 95% CI: 0.98-3.13, P-value = 0.06, I2 = 0%).

Conclusion: CN has a significantly negative impact on outcomes when compared with N-CN.

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冠状动脉钙化结节与非结节性冠状动脉钙化：系统回顾与荟萃分析。

背景：对严重钙化的冠状动脉病变进行经皮冠状动脉介入治疗（PCI）具有挑战性。冠状动脉钙化结节（CN）是指偏心和突出的冠状动脉钙化，与斑块脆弱性和不良临床事件有关。本研究旨在对冠状动脉钙化结节进行广泛综述，重点关注其与非结节性冠状动脉钙化（N-CN）相比对预后的影响：方法：对 PubMed、MEDLINE 和 EMBASE 数据库中的相关文章进行系统性文献综述。方法：在PubMedLINE和MBASE数据库中对相关文章进行了系统性文献综述，纳入了比较冠状动脉钙化和N-冠状动脉钙化的观察性研究或随机对照试验：结果：共纳入了五项比较 CN 和 N-CN 的研究。这些研究的总人数为 1456 人。CN组和N-CN组在基线人口统计学、临床和血管造影数据方面没有明显差异。冠状动脉内成像一直都在使用。在随访中，与 N-CN 相比，CN 与靶血管血运重建[几率比 (OR) 2.16；95% 置信区间 (CI)：1.39-3.36，P 值 < 0.01，I2 = 0%]和支架血栓形成（OR 9.29；95% CI：1.67-51.79，P 值 = 0.01，I2 = 0%）显著增加相关。CN组的心源性死亡也有增加趋势（OR 1.75；95% CI：0.98-3.13，P值=0.06，I2=0%）：结论：与 N-CN 相比，CN 对预后有明显的负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Medicine 医学-心血管系统

CiteScore

3.90

自引率

26.70%

发文量

189

审稿时长

6-12 weeks

期刊介绍： Journal of Cardiovascular Medicine is a monthly publication of the Italian Federation of Cardiology. It publishes original research articles, epidemiological studies, new methodological clinical approaches, case reports, design and goals of clinical trials, review articles, points of view, editorials and Images in cardiovascular medicine. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.