Associations of four surrogate insulin resistance indexes with non-alcoholic steatohepatitis in Chinese patients with obesity: a cross-sectional study.

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Pub Date : 2024-11-01 Epub Date: 2024-05-30 DOI:10.1007/s12020-024-03888-z

Jinfeng Xiao, Xinxin Zhang, Lina Chang, Hong Yu, Longhao Sun, Chonggui Zhu, Qing He

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Abstract

Objectives: This study was designed to evaluate the association of four surrogate indexes of IR with NASH in patients with obesity.

Methods: A total of 270 patients who underwent bariatric surgery, were included in this cross-sectional study. NASH was diagnosed based on liver biopsies. Binary logistics regression analyses were performed to assess the associations of four surrogate indexes of IR (HOMA-IR, Matsuda index, TyG, and TG/HDL-C) with NASH in patients with obesity. The restricted cubic spline was used to assess the dose-response associations of surrogate indexes of IR with NASH after adjusting for confounding factors.

Results: NASH was diagnosed in 136 patients, with a prevalence of 50.37%. Compared with tertile 1, the fully adjusted ORs (95% CIs) of NASH for tertile 3 were 2.711(1.113-6.608) and 0.297 (0.152-0.579) for TyG and Matsuda index. Consistently, per SD increment of TyG were still significantly associated with 64% increased risks of NASH, and per SD increment of Matsuda index were still significantly associated with 38% decreased risks of NASH. In contrast, no significant associations were found between HOMA-IR and TG/HDL-C and the risk of NASH in patients with obesity (all P > 0.05). After adjusting covariates in restricted cubic splines, the risk of NASH decreased with the increment of Matsuda Index levels (P-nonlinear = 0.442, P-overall = 0.007) and with the decrement of TyG levels (P-nonlinear = 0.004, P-overall = 0.001).

Conclusions: In patients with obesity, TyG and Matsuda index were independently related to the risk of NASH after adjustment for traditional risk factors. In addition, compared with HOMA-IR and TG/HDL-C, the Matsuda index and TyG may be more suitable for NASH prediction in patients with obesity.

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中国肥胖症患者的四种代用胰岛素抵抗指数与非酒精性脂肪性肝炎的关系：一项横断面研究。

研究目的本研究旨在评估肥胖症患者 IR 的四项代用指标与 NASH 的相关性：这项横断面研究共纳入了 270 名接受减肥手术的患者。NASH是根据肝脏活检结果确诊的。通过二元物流回归分析，评估肥胖症患者体内四项IR代用指标（HOMA-IR、松田指数、TyG和TG/HDL-C）与NASH的相关性。在调整混杂因素后，使用限制性立方样条曲线评估IR代用指标与NASH的剂量-反应关系：结果：136 名患者确诊为 NASH，发病率为 50.37%。与三分层 1 相比，三分层 3 NASH 的完全调整 ORs（95% CI）为 2.711（1.113-6.608），TyG 和松田指数为 0.297（0.152-0.579）。一致的是，TyG 每标准差增加仍与 NASH 风险增加 64% 显著相关，而松田指数每标准差增加仍与 NASH 风险降低 38% 显著相关。相比之下，HOMA-IR和TG/HDL-C与肥胖患者罹患NASH的风险无明显相关性（P均>0.05）。在限制性三次样板中调整协变量后，NASH风险随松田指数水平的增加而降低（P-非线性=0.442，P-总体=0.007），随TyG水平的降低而降低（P-非线性=0.004，P-总体=0.001）：结论：在对传统风险因素进行调整后，肥胖症患者的TyG和松田指数与NASH风险独立相关。此外，与HOMA-IR和TG/HDL-C相比，松田指数和TyG可能更适合预测肥胖症患者的NASH。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.