Decreased spermatogonial numbers in boys with severe haematological diseases

IF 5.1 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2024-05-29 DOI:10.1111/bjh.19572

Atte K. Lahtinen, Miriam Funke, Claudia Krallmann, Margot J. Wyrwoll, Andrea Jarisch, Yifan Yang, Ragnar Bjarnason, Patrik Romerius, Mikael Sundin, Ulrika Norén-Nyström, Cecilia Langenskiöld, Jann-Frederik Cremers, Sabine Kliesch, Jan-Bernd Stukenborg, Nina Neuhaus, Kirsi Jahnukainen

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Abstract

This study examines spermatogonial numbers in testicular samples from 43 prepubertal patients undergoing haematopoietic stem cell transplantation (HSCT). High-dose chemotherapy and/or radiation during HSCT can impact spermatogenesis requiring fertility preservation. Results show that 49% of patients have decreased and 19% severely depleted spermatogonial pool prior to HSCT. Patients with Fanconi anaemia exhibit significantly reduced spermatogonial numbers. Patients with immunodeficiency or aplastic anaemia generally present within the normal range, while results in patients with myelodysplastic syndrome or myeloproliferative neoplasm vary. The study emphasizes the importance of assessing spermatogonial numbers in patients with severe haematological diseases for informed fertility preservation decisions.

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患有严重血液病的男孩精原细胞数量减少。

本研究检测了 43 名接受造血干细胞移植（HSCT）的青春期前患者睾丸样本中的精原细胞数量。造血干细胞移植期间的大剂量化疗和/或放疗会影响精子发生，需要保留生育能力。结果显示，49%的患者在造血干细胞移植前精原细胞池减少，19%的患者精原细胞池严重枯竭。范可尼贫血患者的精原细胞数量明显减少。免疫缺陷或再生障碍性贫血患者的精原细胞数量一般在正常范围内，而骨髓增生异常综合征或骨髓增生性肿瘤患者的结果则各不相同。这项研究强调了评估严重血液病患者精原细胞数量的重要性，以便在知情的情况下做出保留生育能力的决定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.

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