Performance of a cost-effective olfactory test to evaluate hyposmia in Parkinson's disease patients.

IF 1 4区医学 Q4 NEUROSCIENCES

Arquivos de neuro-psiquiatria Pub Date : 2024-05-01 Epub Date: 2024-05-29 DOI:10.1055/s-0044-1787139

Josevânia Fulgêncio de Lima Arruda, Liene Duarte Silva, Rodrigo Tavares Brisson, Gabriel de Castro Micheli, Marco Antônio Sales Dantas de Lima, Ana Lucia Zuma de Rosso, Rita de Cássia Leite Fernandes

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引用次数: 0

Abstract

Background: Parkinson's disease (PD) causes motor and non-motor symptoms such as hyposmia, which is evaluated through olfactory tests in the clinical practice.

Objective: To assess the feasibility of using the modified Connecticut Chemosensory Clinical Research Center (mCCCRC) olfactory test and to compare its performance with the Sniffin' Sticks-12 (SS-12, Burghart Messtechnik GmbH, Wedel, Germany) test.

Methods: A transversal case-control study in which the patients were divided into the PD group (PDG) and the control group (CG). The cost and difficulty in handling substances to produce the mCCCRC test kits were evaluated. Sociodemographic characteristics, smoking habits, past coronavirus disease 2019 (COVID-19) infections, self-perception of odor sense, and cognition through the Montreal Cognitive Assessment (MoCA) were also evaluated. The PDG was scored by part III of the Unified Parkinson's Disease Rating Scale (UPDRS-III) and the Hoehn and Yahr Scale (H&Y) scale. Correlations were assessed through the Spearman rank correlation coefficient test (ρ, or rho).

Results: The mCCCRC test was easily manufactured and handled at a cost ten times lower compared with the SS-12. The groups (PDG: n = 34; CG: n = 38) were similar in terms of age, sex, level of schooling, smoking habits, and history of COVID-19. The tests results showed moderate correlation (rho = 0.65; p < 0.0001). The CG presented better cognitive performance and scored better in both tests (p < 0.0001). There was a tendency for a negative correlation with age, but good correlation with the MoCA (p = 0.0029). The results of the PDG group showed no correlation with olfactory results and motor performance or disease duration. The self-perception of hyposmia was low in both groups.

Conclusion: The mCCCRC is an easy-to-apply and inexpensive method that demonstrated a similar performance to that of the SS-12 in evaluating olfaction in PD patients and healthy controls.

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经济高效的嗅觉测试评估帕金森病患者的嗅觉减退。

背景：帕金森病（PD）会导致运动和非运动症状，如嗅觉减退：帕金森病（PD）会导致运动和非运动症状，如嗅觉减退，临床上通过嗅觉测试对其进行评估：评估使用改良康涅狄格化感临床研究中心（mCCCRC）嗅觉测试的可行性，并比较其与嗅棒-12（SS-12，Burghart Messtechnik GmbH，Wedel，德国）测试的性能：横向病例对照研究，将患者分为肺结核组（PDG）和对照组（CG）。评估了生产 mCCCRC 检测试剂盒的成本和处理物质的难度。此外，还评估了社会人口学特征、吸烟习惯、既往冠状病毒病 2019（COVID-19）感染情况、对气味的自我感觉以及通过蒙特利尔认知评估（MoCA）得出的认知能力。帕金森病统一评定量表（UPDRS-III）第三部分和Hoehn与Yahr量表（H&Y）对PDG进行了评分。相关性通过斯皮尔曼秩相关系数检验（ρ或rho）进行评估：结果：mCCCRC 检验易于制造和处理，成本比 SS-12 低 10 倍。两组（PDG：n = 34；CG：n = 38）在年龄、性别、受教育程度、吸烟习惯和 COVID-19 病史方面相似。测试结果显示出中等程度的相关性（rho = 0.65；p p = 0.0029）。PDG 组的结果显示，嗅觉结果与运动表现或病程没有相关性。两组患者对嗅觉减退的自我感觉都很低：结论：mCCCRC 是一种易于应用且成本低廉的方法，在评估帕金森病患者和健康对照组的嗅觉方面表现出与 SS-12 相似的性能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de neuro-psiquiatria 医学-精神病学

CiteScore

2.10

自引率

7.10%

发文量

262

审稿时长

4-8 weeks

期刊介绍： Arquivos de Neuro-Psiquiatria is the official journal of the Brazilian Academy of Neurology. The mission of the journal is to provide neurologists, specialists and researchers in Neurology and related fields with open access to original articles (clinical and translational research), editorials, reviews, historical papers, neuroimages and letters about published manuscripts. It also publishes the consensus and guidelines on Neurology, as well as educational and scientific material from the different scientific departments of the Brazilian Academy of Neurology. The ultimate goals of the journal are to contribute to advance knowledge in the areas of Neurology and Neuroscience, and to provide valuable material for training and continuing education for neurologists and other health professionals working in the area. These goals might contribute to improving care for patients with neurological diseases. We aim to be the best Neuroscience journal in Latin America within the peer review system.