James W O'Brien, Ayden Case, Claudia Kemper, Tian X Zhao, Ziad Mallat
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引用次数: 0
Abstract
The adaptive immune system plays an important role in the development and progression of atherosclerotic cardiovascular disease. B cells can have both proatherogenic and atheroprotective roles, making treatments aimed at modulating B cells important therapeutic targets. The innate-like B-cell response is generally considered atheroprotective, while the adaptive response is associated with mixed consequences for atherosclerosis. Additionally, interactions of B cells with components of the adaptive and innate immune system, including T cells and complement, also represent key points for therapeutic regulation. In this review, we discuss therapeutic approaches based on B-cell depletion, modulation of B-cell survival, manipulation of both the antibody-dependent and antibody-independent B-cell response, and emerging immunization techniques.
适应性免疫系统在动脉粥样硬化性心血管疾病的发生和发展过程中扮演着重要角色。B 细胞既能诱发动脉粥样硬化，也能保护动脉粥样硬化，因此，旨在调节 B 细胞的治疗方法是重要的治疗目标。先天性类 B 细胞反应通常被认为具有动脉粥样硬化保护作用，而适应性反应对动脉粥样硬化的影响则好坏参半。此外，B 细胞与适应性和先天性免疫系统成分（包括 T 细胞和补体）的相互作用也是治疗调节的关键点。在这篇综述中，我们将讨论基于 B 细胞耗竭、B 细胞存活调节、抗体依赖性和抗体非依赖性 B 细胞反应操控以及新兴免疫技术的治疗方法。
期刊介绍：
The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA).
The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.
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