Reduction of DUP in early intervention programmes: No pain… almost no gain.

IF 2.1 4区医学 Q3 PSYCHIATRY

Early Intervention in Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-05-28 DOI:10.1111/eip.13580

Morgane Frischherz, Philippe Conus, Philippe Golay

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引用次数: 0

Abstract

Aim: Considering the negative impact of long duration of untreated psychosis (DUP) on outcome, its reduction has become one of the aims of early intervention programmes. The TIPP programme (Treatment and early Intervention in Psychosis Program) was implemented in 2004 in Lausanne and hoped to reduce DUP, without any specific campaign in this regard, through the provision of accessible and specialized treatment. The aim of this study was to evaluate the evolution of patients' DUP over time and the characteristics of patients with extreme DUP.

Methods: Clinical follow-up data of 380 patients aged 18-35 years with a first psychotic episode who entered the TIPP programme between 2004 and 2017 were analysed. The evolution of DUP over time as well as referring entities and destination after the programme were assessed. The characteristics of patients with extreme DUPs (>percentile 90) were compared with that of other patients.

Results: The mean value of the DUP was 452.11 days with a median of 88 days. DUP decreased only moderately over time. We also observe a decrease in discharges to specialized outpatient care at our university hospital. The main characteristics of patients with extreme DUP were early age of onset of psychosis, diagnosis of schizophrenia and presence of history of psychiatric treatment for other conditions before onset of psychosis.

Conclusions: These figures suggest that the DUP has reduced over time but that without specific interventions at this level, this reduction is only moderate.

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减少早期干预计划中的 DUP：没有痛苦......几乎没有收获。

目的：考虑到长期未治疗的精神病（DUP）对治疗效果的负面影响，减少DUP已成为早期干预计划的目标之一。2004 年，洛桑实施了 TIPP 计划（精神病治疗与早期干预计划），希望通过提供方便的专业治疗，减少未治疗时间，但未就此开展任何具体活动。本研究旨在评估患者DUP随时间推移的变化情况以及极端DUP患者的特征：分析了 2004 年至 2017 年间参加 TIPP 计划的 380 名 18-35 岁首次精神病发作患者的临床随访数据。方法：分析了 2004 年至 2017 年期间参加 TIPP 计划的 380 名 18-35 岁首次精神病发作患者的临床随访数据，评估了 DUP 随时间推移的演变情况以及转诊实体和计划后的去向。将DUP极值（>百分位数90）患者的特征与其他患者的特征进行了比较：DUP的平均值为452.11天，中位数为88天。随着时间的推移，DUP 仅略有下降。我们还观察到，本大学医院专科门诊的出院人数也有所减少。极度DUP患者的主要特征是精神病发病年龄早、被诊断为精神分裂症以及在发病前曾因其他疾病接受过精神病治疗：这些数据表明，随着时间的推移，DUP 已经有所减少，但如果不在这一层面采取具体干预措施，这种减少也只是适度的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Early Intervention in Psychiatry 医学-精神病学

CiteScore

4.80

自引率

5.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： Early Intervention in Psychiatry publishes original research articles and reviews dealing with the early recognition, diagnosis and treatment across the full range of mental and substance use disorders, as well as the underlying epidemiological, biological, psychological and social mechanisms that influence the onset and early course of these disorders. The journal provides comprehensive coverage of early intervention for the full range of psychiatric disorders and mental health problems, including schizophrenia and other psychoses, mood and anxiety disorders, substance use disorders, eating disorders and personality disorders. Papers in any of the following fields are considered: diagnostic issues, psychopathology, clinical epidemiology, biological mechanisms, treatments and other forms of intervention, clinical trials, health services and economic research and mental health policy. Special features are also published, including hypotheses, controversies and snapshots of innovative service models.