Migraine and risk of atrial fibrillation: A 9-year follow-up based on the Trøndelag Health Study.

IF 5 2区医学 Q1 CLINICAL NEUROLOGY

Cephalalgia Pub Date : 2024-05-01 DOI:10.1177/03331024241254517

Samita Giri, Erling Tronvik, Håvard Dalen, Hanne Ellekjær, Jan P Loennechen, Alexander Olsen, Knut Hagen

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引用次数: 0

Abstract

Background: Data from some population-based studies have indicated an increased risk of atrial fibrillation (AF) among patients with migraine, particularly among individuals with migraine with aura. The present study aimed to assess the association between primary headache disorders and AF.

Methods: In a population-based 9-year follow-up design, we evaluated the questionnaire-based headache diagnosis, migraine and tension-type headache (TTH) included, collected in the Trøndelag Health Study (HUNT3) conducted in 2006-2008, and the subsequent risk of AF in the period until December 2015. The population at risk consisted of 39,340 individuals ≥20 years without AF at HUNT3 baseline who answered headache questionnaire during HUNT3. The prospective association was evaluated by multivariable Cox proportional hazard models with 95% confidence intervals (CIs).

Results: Among the 39,340 participants, 1524 (3.8%) developed AF during the 9-year follow up, whereof 91% of these were ≥55 years. In the multivariable analyses, adjusting for known confounders, we did not find any association between migraine or TTH and risk of AF. The adjusted hazard ratios (HRs) were respectively 0.84 (95% CI = 0.64-1.11) for migraine, 1.16 (95% CI = 0.86-1.27) for TTH and 1.04 (95% CI = 0.86-1.27) for unclassified headache. However, in sensitivity analyses of individuals aged ≥55 years, a lower risk of AF was found for migraine (HR = 0.53; 95% CI = 0.39-0.73).

Conclusions: In this large population-based study, no increased risk of AF was found among individuals with migraine or TTH at baseline. Indeed, among individuals aged ≥55 years, migraine was associated with a lower risk for AF.

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偏头痛与心房颤动风险：基于特伦德拉格健康研究的 9 年随访。

背景：一些基于人群的研究数据表明，偏头痛患者，尤其是有先兆的偏头痛患者，发生心房颤动（房颤）的风险增加。本研究旨在评估原发性头痛疾病与房颤之间的关联：在一项为期 9 年的基于人群的随访设计中，我们评估了 2006-2008 年开展的特伦德拉格健康研究（HUNT3）中收集的基于问卷的头痛诊断、偏头痛和紧张型头痛（TTH）以及 2015 年 12 月之前的房颤风险。风险人群包括 39,340 名年龄≥20 岁、在 HUNT3 基线时无房颤且在 HUNT3 期间回答过头痛问卷的人。通过多变量考克斯比例危险模型及95%置信区间（CIs）对前瞻性关联进行了评估：在 39340 名参与者中，有 1524 人（3.8%）在 9 年的随访期间患上了房颤，其中 91% 的参与者年龄≥55 岁。在调整已知混杂因素的多变量分析中，我们没有发现偏头痛或TTH与房颤风险之间有任何关联。调整后的危险比（HRs）分别为：偏头痛 0.84（95% CI = 0.64-1.11），TTH 1.16（95% CI = 0.86-1.27），未分类头痛 1.04（95% CI = 0.86-1.27）。然而，在对年龄≥55岁的个体进行的敏感性分析中发现，偏头痛的房颤风险较低（HR = 0.53; 95% CI = 0.39-0.73）：在这项基于人群的大型研究中，没有发现基线时患有偏头痛或TTH的人罹患房颤的风险增加。事实上，在年龄≥55岁的人群中，偏头痛与较低的房颤风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cephalalgia 医学-临床神经学

CiteScore

10.10

自引率

6.10%

发文量

108

审稿时长

4-8 weeks

期刊介绍： Cephalalgia contains original peer reviewed papers on all aspects of headache. The journal provides an international forum for original research papers, review articles and short communications. Published monthly on behalf of the International Headache Society, Cephalalgia''s rapid review averages 5 ½ weeks from author submission to first decision.