Proteomics is advancing the understanding of stallion sperm biology

IF 3.4 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Proteomics Pub Date : 2024-05-29 DOI:10.1002/pmic.202300522

Fernando J. Peña, Francisco Eduardo Martín-Cano, Laura Becerro-Rey, Cristina Ortega-Ferrusola, Gemma Gaitskell-Phillips, Eva da Silva-Álvarez, María Cruz Gil

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Abstract

The mammalian ejaculate is very well suited to proteomics studies. As such, research concerning sperm proteomics is offering a huge amount of new information on the biology of spermatozoa. Among domestic animals, horses represent a species of special interest, in which reproductive technologies and a sizeable market of genetic material have grown exponentially in the last decade. Studies using proteomic approaches have been conducted in recent years, showing that proteomics is a potent tool to dig into the biology of the stallion spermatozoa. The aim of this review is to present an overview of the research conducted, and how these studies have improved our knowledge of stallion sperm biology. The main outcomes of the research conducted so far have been an improved knowledge of metabolism, and its importance in sperm functions, the impact of different technologies on the sperm proteome, and the identification of potential biomarkers. Moreover, proteomics of seminal plasma and phosphoproteomics are identified as areas of major interest.

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蛋白质组学加深了人们对种公马精子生物学的了解。

哺乳动物的射精非常适合蛋白质组学研究。因此，精子蛋白质组学研究为精子生物学提供了大量新信息。在家养动物中，马是一个特别值得关注的物种，在过去的十年中，马的繁殖技术和遗传物质的巨大市场呈指数级增长。近年来利用蛋白质组学方法进行的研究表明，蛋白质组学是研究种马精子生物学的有效工具。本综述旨在概述已开展的研究，以及这些研究如何增进了我们对种公马精子生物学的了解。迄今为止，研究的主要成果是提高了对新陈代谢及其在精子功能中重要性的认识、不同技术对精子蛋白质组的影响以及潜在生物标志物的鉴定。此外，精浆蛋白质组学和磷酸蛋白质组学也被确定为主要研究领域。

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来源期刊

Proteomics 生物-生化研究方法

CiteScore

6.30

自引率

5.90%

发文量

193

审稿时长

3 months

期刊介绍： PROTEOMICS is the premier international source for information on all aspects of applications and technologies, including software, in proteomics and other "omics". The journal includes but is not limited to proteomics, genomics, transcriptomics, metabolomics and lipidomics, and systems biology approaches. Papers describing novel applications of proteomics and integration of multi-omics data and approaches are especially welcome.