Exploring the impact of recent COVID-19 infection on perfusion and functional parameters derived from gated myocardial perfusion imaging in patients undergoing evaluation for coronary artery disease

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Annals of Nuclear Medicine Pub Date : 2024-05-28 DOI:10.1007/s12149-024-01946-0

Maryam Alvandi, Zahra Shaghaghi, Zhino Fatehi, Behshad Naghshtabrizi, Tayeb Mohammadi, Safoora Nikzad

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引用次数: 0

Abstract

Objective

This study seeks to evaluate how recent COVID-19 infection affects myocardial perfusion and functional parameters derived from gated myocardial perfusion imaging in patients undergoing evaluation for coronary artery disease. The goal is to enhance our understanding of COVID-19’s influence on the cardiovascular system.

Method

Conducted at Farshchian Heart Hospital from 2022 to 2023, this case–control study enrolled patients suspected of coronary artery disease, stratified into two groups: those with confirmed COVID-19 infection within the past 6 months (study group) and those without prior COVID-19 infection (control group). Employing a 2-day protocol, stress testing and gated SPECT MPI were performed. Statistical analysis included descriptive statistics, Chi-square test, Student’s t test, and Mann–Whitney U test.

Result

Among the 86 patients included, 43 were in each group. Significantly higher summed stress core and summed difference score values were observed in the study group compared to the control group (p < 0.05). In addition, the study group exhibited significantly altered global left ventricular ejection fraction, end-diastolic volume, and end-systolic volume (p < 0.05). Non-perfusion findings, including transient ischemic dilation and transient right ventricular visualization, were more prevalent in the study group.

Conclusion

Recent COVID-19 infection is associated with impaired myocardial perfusion and altered functional parameters as detected by MPI. These findings underscore the intricate interplay between COVID-19 and cardiovascular health, emphasizing the importance of comprehensive evaluation and management strategies to address cardiac complications in affected individuals. Further research is warranted to elucidate the underlying mechanisms and optimize patient care in the context of COVID-19-associated cardiovascular manifestations.

查看原文本刊更多论文

探讨近期感染 COVID-19 对接受冠状动脉疾病评估的患者门控心肌灌注成像得出的灌注和功能参数的影响。

研究目的本研究旨在评估 COVID-19 近期感染如何影响接受冠状动脉疾病评估的患者的心肌灌注和门控心肌灌注成像得出的功能参数。目的是加深我们对 COVID-19 对心血管系统影响的了解：这项病例对照研究于 2022 年至 2023 年在 Farshchian 心脏病医院进行，研究对象为疑似冠心病患者，分为两组：过去 6 个月内确诊感染 COVID-19 的患者（研究组）和未感染 COVID-19 的患者（对照组）。研究组采用为期两天的方案，进行压力测试和门控 SPECT MPI。统计分析包括描述性统计、卡方检验、学生 t 检验和 Mann-Whitney U 检验：结果：在纳入的 86 名患者中，每组 43 人。结果：在纳入的 86 名患者中，每组 43 人，研究组与对照组相比，应激核心总和及差异总和评分值明显较高（P近期感染 COVID-19 与心肌灌注受损和 MPI 检测到的功能参数改变有关。这些发现凸显了 COVID-19 与心血管健康之间错综复杂的相互作用，强调了全面评估和管理策略对于解决受影响人群心脏并发症的重要性。在 COVID-19 相关心血管表现的背景下，有必要开展进一步研究，以阐明其潜在机制并优化患者护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.