Emerging Insights into Postoperative Neurocognitive Disorders: The Role of Signaling Across the Gut-Brain Axis.

IF 4.6 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2024-12-01 Epub Date: 2024-05-27 DOI:10.1007/s12035-024-04228-y

Wanqiu Yu, Zhaoqiong Zhu, Fushan Tang

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引用次数: 0

Abstract

The pathophysiological regulatory mechanisms in postoperative neurocognitive disorders (PNCDs) are intricately complex. Currently, the pathogenesis of PNCDs has not been fully elucidated. The mechanism involved may include a variety of factors, such as neuroinflammation, oxidative stress, and neuroendocrine dysregulation. Research into the gut microbiota-induced regulations on brain functions is increasingly becoming a focal point of exploration. Emerging evidence has shown that intestinal bacteria may play an essential role in maintaining the homeostasis of various physiological systems and regulating disease occurrence. Recent studies have confirmed the association of the gut-brain axis with central nervous system diseases. However, the regulatory effects of this axis in the pathogenesis of PNCDs remain unclear. Therefore, this paper intends to review the bidirectional signaling and mechanism of the gut-brain axis in PNCDs, summarize the latest research progress, and discuss the possible mechanism of intestinal bacteria affecting nervous system diseases. This review is aimed at providing a scientific reference for predicting the clinical risk of PNCD patients and identifying early diagnostic markers and prevention targets.

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术后神经认知障碍的新见解：肠道-大脑轴信号传递的作用。

术后神经认知障碍（PNCD）的病理生理调节机制错综复杂。目前，PNCDs 的发病机制尚未完全阐明。其中涉及的机制可能包括神经炎症、氧化应激和神经内分泌失调等多种因素。对肠道微生物诱导的大脑功能调节的研究正日益成为探索的焦点。新的证据表明，肠道细菌可能在维持各种生理系统的平衡和调节疾病发生方面发挥着重要作用。最近的研究证实，肠脑轴与中枢神经系统疾病有关。然而，该轴在 PNCD 发病机制中的调控作用仍不清楚。因此，本文旨在回顾肠脑轴在 PNCDs 中的双向信号传导和机制，总结最新的研究进展，并探讨肠道细菌影响神经系统疾病的可能机制。本综述旨在为预测 PNCD 患者的临床风险、确定早期诊断标志物和预防目标提供科学参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.