Study of expression of GLUT-1 in oral potentially malignant disorders and oral squamous cell carcinoma: An immuno-histochemical analysis.

Q3 Medicine

Journal of Oral and Maxillofacial Pathology Pub Date : 2024-01-01 Epub Date: 2024-04-15 DOI:10.4103/jomfp.jomfp_474_23

Shylaja K Attur, Anil Patel, Kailash M Attur

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引用次数: 0

Abstract

Background: Glucose is the chief source of energy for cells, and glucose transporter 1 (GLUT-1) is one of the most common glucose transporters in humans. Tumour cells are known to express hypoxia-related protein, and these may allow tumour cells to survive under a sustained hypoxic environment. Surviving cells develop a more aggressive phenotype, which results in poor prognosis.

Aims and objectives: Expression and comparison of GLUT-1 in normal tissues, potentially malignant disorders (PMDs), and oral squamous cell carcinoma (OSCC) and comparison of expression in different grades of OSCC.

Material and methods: A total of 57 cases (10 normal, 17 PMD, and 30 cases of OSCC) were stained immuno-histochemically with GLUT-1. The expression was scored as 0, 1, 2, 3, and 4 for negative, mild, moderate, severe, and intense staining, respectively.

Results: GLUT-1 expression was detected in all grades of OSCC. A significant correlation was found on comparing normal and OSCC, normal and PMDs, and PMD and OSCC. The expression of GLUT-1 was significant when compared with different histopathological grades of OSCC.

Conclusions: Expression of GLUT-1 increased from normal to PMDs to increasing grades of OSCC and hence can be used as a prognostic predictive marker for OSCC.

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口腔潜在恶性疾病和口腔鳞状细胞癌中 GLUT-1 的表达研究：免疫组织化学分析。

背景：葡萄糖是细胞的主要能量来源，而葡萄糖转运体 1 (GLUT-1) 是人类最常见的葡萄糖转运体之一。众所周知，肿瘤细胞会表达缺氧相关蛋白，这些蛋白可使肿瘤细胞在持续缺氧的环境中存活下来。存活下来的细胞会形成更具侵袭性的表型，从而导致预后不良：GLUT-1 在正常组织、潜在恶性疾病（PMDs）和口腔鳞状细胞癌（OSCC）中的表达和比较，以及在不同等级 OSCC 中的表达比较：对 57 个病例（10 个正常病例、17 个潜在恶性疾病病例和 30 个 OSCC 病例）进行 GLUT-1 免疫组织化学染色。阴性、轻度、中度、重度和强染色分别记为 0、1、2、3 和 4：结果：GLUT-1在所有等级的OSCC中均有表达。在比较正常与 OSCC、正常与 PMD、PMD 与 OSCC 时发现了明显的相关性。GLUT-1的表达与不同组织病理学分级的OSCC相比有显著性差异：结论：GLUT-1的表达量从正常到PMDs再到OSCC级别的增加，因此可作为OSCC的预后预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral and Maxillofacial Pathology Medicine-Otorhinolaryngology

CiteScore

1.40

自引率

0.00%

发文量

115

期刊介绍： The journal of Oral and Maxillofacial Pathology [ISSN:print-(0973-029X, online-1998-393X)] is a tri-annual journal published on behalf of “The Indian Association of Oral and Maxillofacial Pathologists” (IAOMP). The publication of JOMFP was started in the year 1993. The journal publishes papers on a wide spectrum of topics associated with the scope of Oral and Maxillofacial Pathology, also, ensuring scientific merit and quality. It is a comprehensive reading material for the professionals who want to upgrade their diagnostic skills in Oral Diseases; allows exposure to newer topics and methods of research in the Oral-facial Tissues and Pathology. New features allow an open minded thinking and approach to various pathologies. It also encourages authors to showcase quality work done by them and to compile relevant cases which are diagnostically challenging. The Journal takes pride in maintaining the quality of articles and photomicrographs.