Diagnostic accuracy and clinical impact of renal biopsy cytology

IF 1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Diagnostic Cytopathology Pub Date : 2024-05-27 DOI:10.1002/dc.25357

Hongzhi Xu MD, PhD, Ian A. Taylor-Cho BA, Xiaoyin “Sara” Jiang MD, Wen-Chi Foo MD

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引用次数: 0

Abstract

Background

The role of fine needle biopsy cytology in the workup of renal mass lesions remains controversial. With advances in imaging technology and clinical management for renal masses, a critical reevaluation of the role of renal biopsy is needed. This study was designed to provide a comprehensive evaluation of the performance and clinical impact of fine needle biopsy in patients with renal masses.

Methods

A 5-year retrospective study of ultrasound or computer tomography (CT)-guided fine needle biopsies of renal masses diagnosed via cytopathology was conducted. Overall diagnostic rate, sensitivity, and diagnostic accuracy were calculated. Further analysis of the impact of fine needle biopsy cytology on clinical management was performed.

Results

A total of 227 cases of fine-needle aspiration and/or biopsy (FNA/B) of renal masses were identified, including 76 with subsequent nephrectomies. Complications were rare (<1%). The diagnostic rate and sensitivity of FNA/B were 83.3% and 89.5%, respectively. Diagnostic accuracy was 98.7% at the major categorical level and 94.7% at the tumor subtype level. Subsequent clinical actions were associated with a definitive cytologic diagnosis of malignancy/neoplasia (p < .05) and were affected by tumor subtype (p < .05).

Conclusion

This study demonstrates that FNA/B of renal masses is a safe and reliable minimally invasive diagnostic tool with excellent accuracy in confirmation of malignancy and subclassification of tumors. Diagnoses made on FNA/B play a key role in guiding a personalized clinical treatment plan.

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肾活检细胞学的诊断准确性和临床影响。

背景：细针活检细胞学在肾脏肿块病变检查中的作用仍存在争议。随着成像技术和肾脏肿块临床治疗的进步，需要对肾脏活检的作用进行重新评估。本研究旨在全面评估肾肿块患者细针活检的效果和临床影响：对通过细胞病理学诊断的肾肿块进行超声或计算机断层扫描（CT）引导的细针活检进行了一项为期 5 年的回顾性研究。研究计算了总体诊断率、敏感性和诊断准确性。进一步分析了细针活检细胞学对临床治疗的影响：结果：共发现 227 例肾脏肿块细针穿刺和/或活检（FNA/B）病例，其中 76 例随后进行了肾切除术。并发症极少发生（结论：该研究表明，肾肿块的 FNA/B 切除术是一种有效的治疗方法：本研究表明，肾肿块 FNA/B 是一种安全可靠的微创诊断工具，在确认恶性肿瘤和肿瘤亚分类方面具有极高的准确性。FNA/B 诊断在指导个性化临床治疗方案方面发挥着关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic Cytopathology 医学-病理学

CiteScore

2.60

自引率

7.70%

发文量

163

审稿时长

3-6 weeks

期刊介绍： Diagnostic Cytopathology is intended to provide a forum for the exchange of information in the field of cytopathology, with special emphasis on the practical, clinical aspects of the discipline. The editors invite original scientific articles, as well as special review articles, feature articles, and letters to the editor, from laboratory professionals engaged in the practice of cytopathology. Manuscripts are accepted for publication on the basis of scientific merit, practical significance, and suitability for publication in a journal dedicated to this discipline. Original articles can be considered only with the understanding that they have never been published before and that they have not been submitted for simultaneous review to another publication.