Revolutionizing Cancer Treatment: Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment.

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-05-23 DOI:10.2174/0115680266299112240514103048

Shahram Taeb, Davoud Rostamzadeh, Seyed Mohammad Amini, Mohamad Rahmati, Mostafa Golshekan, Mahmoud Abedinzadeh, Elham Ahmadi, Singh Neha, Masoud Najafi

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引用次数: 0

Abstract

In recent years, mesenchymal stem cells (MSCs) have emerged as promising anti-- cancer mediators with the potential to treat several cancers. MSCs have been modified to produce anti-proliferative, pro-apoptotic, and anti-angiogenic molecules that could be effective against a variety of malignancies. Additionally, customizing MSCs with cytokines that stimulate pro-tumorigenic immunity or using them as vehicles for traditional chemical molecules with anti-cancer characteristics. Even though the specific function of MSCs in tumors is still challenged, promising outcomes from preclinical investigations of MSC-based gene therapy for a variety of cancers inspire the beginning of clinical trials. In addition, the tumor microenvironment (TME) could have a substantial influence on normal tissue stem cells, which can affect the treatment outcomes. To overcome the complications of TME in cancer development, MSCs could provide some signs of hope for converting TME into unequivocal therapeutic tools. Hence, this review focuses on engineered MSCs (En-MSCs) as a promising approach to overcoming the complications of TME.

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革命性的癌症治疗：利用间充质干细胞的力量在肿瘤微环境中进行精确的靶向治疗》（Harnessing the Power of Mesenchymal Stem Cells for Precise Targeted Therapy in the Tumor Microenvironment）。

近年来，间充质干细胞（MSCs）已成为有望治疗多种癌症的抗癌介质。间充质干细胞经改造后可产生抗增殖、促凋亡和抗血管生成分子，可有效对抗多种恶性肿瘤。此外，利用细胞因子定制间充质干细胞，可刺激促肿瘤免疫，或将间充质干细胞用作具有抗癌特性的传统化学分子的载体。尽管间充质干细胞在肿瘤中的具体功能仍面临挑战，但基于间充质干细胞的基因疗法对多种癌症的临床前研究取得了可喜的成果，这激励着临床试验的开始。此外，肿瘤微环境（TME）会对正常组织干细胞产生重大影响，从而影响治疗效果。为了克服肿瘤微环境在癌症发展中的复杂性，间充质干细胞可为将肿瘤微环境转化为明确的治疗工具提供一些希望。因此，本综述将重点关注工程间充质干细胞（En-MSCs），将其作为克服TME并发症的一种有前途的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.