Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-05-27 DOI:10.1186/s13550-024-01111-8

David Morland, Lukshe Kanagaratnam, Fabrice Hubelé, Elise Toussaint, Sylvain Choquet, Aurélie Kas, Pierre-Ambroise Caquot, Corinne Haioun, Emmanuel Itti, Stéphane Leprêtre, Pierre Decazes, Fontanet Bijou, Paul Schwartz, Caroline Jacquet, Adrien Chauchet, Julien Matuszak, Nassim Kamar, Pierre Payoux, Eric Durot

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引用次数: 0

Abstract

Background: Besides International Prognostic Index (IPI) score, baseline prognostic factors of post-transplant lymphoproliferative disorders (PTLD) are poorly identified due to the rarity of the disease. New indexes derived from healthy organ uptake in baseline 18F-FDG PET/CT have been studied in immunocompetent lymphoma patients. The aim of this study is to evaluate the performances of the cerebellum-to-liver uptake ratio (denoted as CLIP) as a prognostic factor for PFS and OS. This retrospective multicenter study is based on patients with PTLD included in the K-VIROGREF cohort. The previously published threshold of 3.24 was used for CLIP in these analyses.

Results: A total of 97 patients was included with a majority of monomorphic diffuse large B-cell lymphoma subtype (78.3%). Both IPI score (≥ 3) and CLIP (< 3.24) were significant risk factors of PFS with corresponding hazard ratios of 2.0 (1.0-4.0) and 2.4 (1.3-4.5) respectively. For OS, CLIP was not significant and resulted in a hazard ratio of 2.6 (p = 0.059). Neither IPI score or Total Metabolic Tumor Volume reached significance for OS.

Conclusion: CLIP is a promising predictor of PFS and perhaps OS in PTLD. Further prospective studies are needed to confirm these results.

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基线18F-FDG PET/CT上的小脑/肝脏指数改善移植后淋巴组织增生性疾病的预后：一项多中心回顾性研究。

背景：除国际预后指数（IPI）评分外，移植后淋巴组织增生性疾病（PTLD）的基线预后因素因其罕见性而鲜为人知。根据基线18F-FDG PET/CT中健康器官摄取量得出的新指标已在免疫功能正常的淋巴瘤患者中进行了研究。本研究旨在评估小脑与肝脏摄取比值（CLIP）作为PFS和OS预后因素的性能。这项回顾性多中心研究基于 K-VIROGREF 队列中的 PTLD 患者。在这些分析中，CLIP采用了之前公布的阈值3.24：共纳入了 97 例患者，其中大多数为单形弥漫大 B 细胞淋巴瘤亚型（78.3%）。IPI评分（≥3）和CLIP（结论：CLIP是预测弥漫大B细胞淋巴瘤亚型的有效指标：CLIP是预测PTLD患者PFS和OS的有效指标。需要进一步的前瞻性研究来证实这些结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567