Heba-Tallah Abd Elrahim Abd Elkader, Amina E. Essawy, Ahmed S. Al-Shami
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引用次数: 0
Abstract
Multiple neurological diseases are becoming increasingly common, posing a major public health concern around the world. The multifactorial pathophysiology of this debilitating disease, as well as the diverse effects of active constituents of microalgal medicine, as well as the drawbacks and lack of clinical treatments, may advocate for the discovery of new natural compounds with strong neuroprotective potential for treatment. Spirulina is a free-floating filamentous microalga that belongs to the cyanobacteria class and contains a variety of bioactive colored components such as C-phycocyanin (C-Pc), carotenoids, and chlorophyll. Modern pharmacological and molecular docking studies have demonstrated that Spirulina has disease-modifying therapeutic effects against these disorders, including neuroprotection, protein aggregate clearance, and neuroinflammation regulation. The study’s goal is to determine the benefits of Spirulina and its active constituents in the treatment of various neurodegenerative and neuropsychiatric diseases. This review summarizes evidence from in vitro, in vivo, and in silico research studies on neurological therapies focusing on the neuroprotective activities and molecular mechanisms of Spirulina and their active ingredients, with a focus on modulating various neurotransmitters and receptors, anti-inflammatory activities, anti-amyloid aggregation, and myelin sheath repair. The direct interaction between major active components of Spirulina sp. and orphan nuclear receptors, monoamine oxidase (MAO), bovine serum albumin (BSA), and pro-inflammatory proteins was modelled using molecular docking. This review’s findings support the use of Spirulina and its biologically active constituents as an alternative source of therapy for neurological diseases.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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