Advancements in three-dimensional bioprinting for reproductive medicine: a systematic review

IF 3.7 2区医学 Q1 OBSTETRICS & GYNECOLOGY

Reproductive biomedicine online Pub Date : 2024-05-21 DOI:10.1016/j.rbmo.2024.104273

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引用次数: 0

Abstract

Reproductive failure due to age, genetics and disease necessitates innovative solutions. While reproductive tissue transplantation has advanced, ongoing research seeks superior approaches. Biomaterials, bioengineering and additive manufacturing, such as three-dimensional (3D) bioprinting, are harnessed to restore reproductive function. 3D bioprinting uses materials, cells and growth factors to mimic natural tissues, proving popular for tissue engineering, notably in complex scaffold creation with cell distribution. The versatility which is brought to reproductive medicine by 3D bioprinting allows more accurate and on-site applicability to various problems that are encountered in the field. However, in the literature, there is a lack of studies encompassing the valuable applications of 3D bioprinting in reproductive medicine. This systematic review aims to improve understanding, and focuses on applications in several branches of reproductive medicine. Advancements span the restoration of ovarian function, endometrial regeneration, vaginal reconstruction, and male germ cell bioengineering. 3D bioprinting holds untapped potential in reproductive medicine.

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用于生殖医学的三维生物打印技术进展：系统综述

由于年龄、遗传和疾病导致的生殖功能衰竭需要创新的解决方案。虽然生殖组织移植已经取得了进展，但目前的研究仍在寻求更优越的方法。生物材料、生物工程和增材制造（如三维（3D）生物打印）被用来恢复生殖功能。三维生物打印利用材料、细胞和生长因子来模拟天然组织，在组织工程方面很受欢迎，特别是在创建复杂的细胞分布支架方面。三维生物打印技术为生殖医学带来了多功能性，可以更准确、更现场地解决生殖医学领域遇到的各种问题。然而，文献中缺乏对三维生物打印在生殖医学中的宝贵应用的研究。这篇系统性综述旨在增进人们的了解，重点关注生殖医学多个分支的应用。研究进展涵盖卵巢功能恢复、子宫内膜再生、阴道重建和男性生殖细胞生物工程。三维生物打印在生殖医学领域的潜力尚待开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reproductive biomedicine online 医学-妇产科学

CiteScore

7.20

自引率

7.50%

发文量

391

审稿时长

50 days

期刊介绍： Reproductive BioMedicine Online covers the formation, growth and differentiation of the human embryo. It is intended to bring to public attention new research on biological and clinical research on human reproduction and the human embryo including relevant studies on animals. It is published by a group of scientists and clinicians working in these fields of study. Its audience comprises researchers, clinicians, practitioners, academics and patients. Context: The period of human embryonic growth covered is between the formation of the primordial germ cells in the fetus until mid-pregnancy. High quality research on lower animals is included if it helps to clarify the human situation. Studies progressing to birth and later are published if they have a direct bearing on events in the earlier stages of pregnancy.