Correction of plasma fat-soluble vitamin levels by blood lipids in elderly patients with coronary heart disease

IF 1.7 Q3 MEDICAL LABORATORY TECHNOLOGY

Practical Laboratory Medicine Pub Date : 2024-05-01 DOI:10.1016/j.plabm.2024.e00404

Xin-Yu Wang , Xiangzhi Liu , Chengliang Zhen , Nannan Tian , Haina Ma , Menghan Wang , Li Wang

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Abstract

This study aims to investigate the correlation between plasma fat-soluble vitamin levels and blood lipid in elderly patients with coronary heart disease (CHD). A total of 120 participants were enrolled, including 60 CHD patients and 60 controls without CHD. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to quantify plasma levels of vitamins A, D₃, E, and K. Data analysis was conducted using the statistical analysis system module of MetaboAnalyst 5.0. The CHD group showed significantly higher levels of plasma total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) but not high-density lipoprotein cholesterol (HDL-C) compared to controls. The CHD group exhibited significantly higher plasma levels of VA and VE, positively correlating with TC, TG, and LDL-C. After adjusted by TG levels, the CHD group had significantly lower plasma levels of VA and VE, negatively correlating with TC, TG, and LDL-C. The CHD group also had significantly lower concentrations of VD₃, independent of TG modification, compared to controls. VD₃ negatively correlated with TC, TG, and LDL-C. Elderly individuals with CHD display abnormal blood lipid metabolism, and fat-soluble vitamins adjusted by TG levels can more accurately and timely response to implicit fat-soluble vitamins deficiency in CHD patients.

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通过血脂校正老年冠心病患者的血浆脂溶性维生素水平

本研究旨在探讨老年冠心病（CHD）患者血浆脂溶性维生素水平与血脂之间的相关性。研究共招募了 120 名参与者，包括 60 名冠心病患者和 60 名非冠心病对照组。采用液相色谱-串联质谱法（LC-MS/MS）定量检测血浆中维生素A、D3、E和K的含量。与对照组相比，CHD组的血浆总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平明显较高，但高密度脂蛋白胆固醇（HDL-C）水平并不高。心脏病组的血浆 VA 和 VE 水平明显较高，与 TC、TG 和 LDL-C 呈正相关。根据 TG 水平进行调整后，CHD 组的血浆 VA 和 VE 水平明显较低，与 TC、TG 和 LDL-C 呈负相关。与对照组相比，冠心病组的 VD3 浓度也明显较低，与 TG 的变化无关。VD3 与总胆固醇、总胆固醇和低密度脂蛋白胆固醇呈负相关。患有冠心病的老年人血脂代谢异常，根据 TG 水平调整脂溶性维生素可以更准确、更及时地应对冠心病患者隐性脂溶性维生素缺乏的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Practical Laboratory Medicine Health Professions-Radiological and Ultrasound Technology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

7 weeks

期刊介绍： Practical Laboratory Medicine is a high-quality, peer-reviewed, international open-access journal publishing original research, new methods and critical evaluations, case reports and short papers in the fields of clinical chemistry and laboratory medicine. The objective of the journal is to provide practical information of immediate relevance to workers in clinical laboratories. The primary scope of the journal covers clinical chemistry, hematology, molecular biology and genetics relevant to laboratory medicine, microbiology, immunology, therapeutic drug monitoring and toxicology, laboratory management and informatics. We welcome papers which describe critical evaluations of biomarkers and their role in the diagnosis and treatment of clinically significant disease, validation of commercial and in-house IVD methods, method comparisons, interference reports, the development of new reagents and reference materials, reference range studies and regulatory compliance reports. Manuscripts describing the development of new methods applicable to laboratory medicine (including point-of-care testing) are particularly encouraged, even if preliminary or small scale.