Daria V. Tsyupka, Yuliya A. Podkolodnaya, Ekaterina A. Khudina, Daria G. Koganova, Olga A. Goryacheva, Anna M. Abramova, Irina Yu Goryacheva
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引用次数: 0
Abstract
Anthracycline antibiotics (doxorubicin, daunorubicin, mitoxantrone, idarubicin, epirubicin, ect.) are widely used in chemotherapy of various diseases, effectively destroying cancer cells, but also affecting healthy cells and organs. Clinical monitoring of anthracycline antibiotics in biofluids is critical for optimization of therapy and minimization of side effects, since toxicity increases at too high concentrations, while desired chemotherapy effects may be reduced or lost at too low concentrations. The development of approaches based on the luminescence quenching of nanosensors makes it possible to develop simple fast inexpensive methods for monitoring anthracycline antibiotics on the basis of their intrinsic properties. The advantages of turn-off luminescence nanosensors are discussed, a closer look is given to the applications for anthracycline antibiotics analysis in biofluids with focus on their limitations.
期刊介绍:
TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.