Laser-induced fabrication of doped-graphene based on collagen for bone tissue engineering scaffold applications

IF 3.2 3区 工程技术 Q2 ENGINEERING, INDUSTRIAL
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引用次数: 0

Abstract

Electro-active scaffolds play an important role in bone tissue engineering applications, serving as physical substrates for cell proliferation and osteogenic differentiation, ultimately realizing new bone regeneration. This paper discusses a novel strategy to synthesize graphene through laser-induced surface doping, using bone collagen as the carbon source, serving as a key functional filler to be combined with biocompatible, biodegradable poly(ε-caprolactone) (PCL), for the fabrication of the next generation electro-active bone tissue engineering scaffolds. Scaffolds are fabricated through material-extrusion additive manufacturing. The developed graphene is proven to present a significant enhancement effect on surface and mechanical properties over the conventional graphene material.

激光诱导制备基于胶原蛋白的掺杂石墨烯,用于骨组织工程支架应用
电活性支架在骨组织工程应用中发挥着重要作用,可作为细胞增殖和成骨分化的物理基底,最终实现新骨再生。本文讨论了一种通过激光诱导表面掺杂合成石墨烯的新策略,以骨胶原蛋白为碳源,作为一种关键的功能填料,与生物相容性、可生物降解的聚(ε-己内酯)(PCL)相结合,用于制造下一代电活性骨组织工程支架。支架是通过材料挤出增材制造法制造的。事实证明,与传统的石墨烯材料相比,所开发的石墨烯在表面和机械性能方面具有显著的增强效果。
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来源期刊
Cirp Annals-Manufacturing Technology
Cirp Annals-Manufacturing Technology 工程技术-工程:工业
CiteScore
7.50
自引率
9.80%
发文量
137
审稿时长
13.5 months
期刊介绍: CIRP, The International Academy for Production Engineering, was founded in 1951 to promote, by scientific research, the development of all aspects of manufacturing technology covering the optimization, control and management of processes, machines and systems. This biannual ISI cited journal contains approximately 140 refereed technical and keynote papers. Subject areas covered include: Assembly, Cutting, Design, Electro-Physical and Chemical Processes, Forming, Abrasive processes, Surfaces, Machines, Production Systems and Organizations, Precision Engineering and Metrology, Life-Cycle Engineering, Microsystems Technology (MST), Nanotechnology.
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