Progesterone affects periodontitis in perimenopausal women and in an experimental rat model

IF 3.4 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Dental Sciences Pub Date : 2025-01-01 DOI:10.1016/j.jds.2024.05.020

Ying Man , Xin-yue Zhang , Xiao-zhen Wang , Si-yu Liu , Fei-fei Niu , Pi-shan Yang

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Abstract

Background/purpose

Progesterone (PG) is sex steroid hormone that commonly used to control menopausal symptoms, but its exact role in periodontitis remains unclear. This study aimed to investigate the effects of PG on periodontitis in perimenopausal women and in an experimental rat model.

Materials and methods

Total 412 perimenopausal women with periodontitis and a history of PG deficiency-induced uterine dysfunctional bleeding were enrolled, among which 209 women had been treated with PG. The alveolar bone height (ABH) and bone mineral density (BMD) were measured by cone beam computed tomography in the full-mouth. Additionally, a ligation-induced rat model of periodontitis was established. After treated with PG, the alveolar bone was evaluated by micro-computed tomography, and the expression of osteogenic and inflammatory markers was evaluated by immunohistochemistry. The levels of inflammatory markers were further measured by enzyme linked immunosorbent assay.

Results

In perimenopausal women with periodontitis, significantly lower maximum mesial ABH and higher minimum lingual/palatal BMD were revealed in the PG group than in the control group. Compared with the control group, the mean values of BMD around all teeth were significantly higher in the PG group. In a rat model of periodontitis, the intervention of PG significantly improved the quality of alveolar bone, up-regulated osteogenic markers, and down-regulated inflammatory markers.

Conclusion

PG is associated with the remission of alveolar bone loss in perimenopausal women with periodontitis. PG may contribute to the remission of periodontitis through inhibiting alveolar bone loss and inflammation.

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来源期刊

Journal of Dental Sciences 医学-牙科与口腔外科

CiteScore

5.10

自引率

14.30%

发文量

348

审稿时长

6 days

期刊介绍： he Journal of Dental Sciences (JDS), published quarterly, is the official and open access publication of the Association for Dental Sciences of the Republic of China (ADS-ROC). The precedent journal of the JDS is the Chinese Dental Journal (CDJ) which had already been covered by MEDLINE in 1988. As the CDJ continued to prove its importance in the region, the ADS-ROC decided to move to the international community by publishing an English journal. Hence, the birth of the JDS in 2006. The JDS is indexed in the SCI Expanded since 2008. It is also indexed in Scopus, and EMCare, ScienceDirect, SIIC Data Bases. The topics covered by the JDS include all fields of basic and clinical dentistry. Some manuscripts focusing on the study of certain endemic diseases such as dental caries and periodontal diseases in particular regions of any country as well as oral pre-cancers, oral cancers, and oral submucous fibrosis related to betel nut chewing habit are also considered for publication. Besides, the JDS also publishes articles about the efficacy of a new treatment modality on oral verrucous hyperplasia or early oral squamous cell carcinoma.