Relationship between fortilin levels and coronary ischemia in heart failure

The European Research Journal Pub Date : 2024-05-18 DOI:10.18621/eurj.1447544

Sümeyra Gökçek, Cihan Aydın, Aykut Demirkıran, Şeref Alpsoy

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Abstract

Objective: Fortilin is a multifunctional protein that protects cells against apoptosis. We aimed to investigate the levels of fortilin in patients with heart failure. Methods: Patients with ejection fraction (EF) below 40% were divided into two groups according to coronary angiography results: those with ischemic heart failure (Group 1) and those with non-ischemic heart failure (Group 2). Patients with normal anatomy and EF over 50% were included in the control group (Group 3). Results: A total of 119 patients were prospectively included in the study. A total of 81 patients (41 patients with ischemic heart failure and 40 patients with non-ischemic heart failure) were included in the heart failure group. 38 patients with EF >50 and normal coronary anatomy were included in the control group. There was no significant difference in serum fortilin levels between the study groups (Group 1: 5.5±2.6 ng/mL, Group 2: 6.1±3.8 ng/mL, and Group 3: 5.6±3.6 ng/mL; P=0.693). Fortilin did not show a correlation with any other variables. Conclusion: In our study, there was no significant difference in fortilin levels between the groups, and no relationship was found between coronary ischemia and fortilin levels in heart failure.

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福替林水平与心力衰竭患者冠状动脉缺血之间的关系

目的Fortilin是一种多功能蛋白质，可保护细胞免受凋亡。我们旨在研究心力衰竭患者体内福替林的水平：根据冠状动脉造影结果，将射血分数（EF）低于 40% 的患者分为两组：缺血性心力衰竭患者（第 1 组）和非缺血性心力衰竭患者（第 2 组）。解剖结构正常且 EF 超过 50%的患者被纳入对照组（第 3 组）：共有 119 名患者被纳入前瞻性研究。心衰组共有 81 名患者（41 名缺血性心衰患者和 40 名非缺血性心衰患者）。38 名 EF >50 且冠状动脉解剖正常的患者被纳入对照组。研究组之间的血清福替林水平无明显差异（第 1 组：5.5±2.6 ng/mL；第 2 组：6.1±3.8 ng/mL；第 3 组：5.6±3.6 ng/mL；P=0.693）。结论：结论：在我们的研究中，各组间的福替林水平无明显差异，也未发现冠状动脉缺血与心衰患者的福替林水平之间存在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The European Research Journal

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