An Exploratory Review on Recent Computational Approaches Devised for MiRNA Disease Association Prediction

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-05-20 DOI:10.2174/0115748936293219240426051148

S Sujamol, E R Vimina, U. Krishnakumar

引用次数: 0

Abstract

Recent evidence demonstrated the fundamental role of miRNAs as disease biomarkers and their role in disease progression and pathology. Identifying disease related miRNAs using computational approaches has become one of the trending topics in health informatics. Many biological databases and online tools were developed for uncovering novel disease-related miRNAs. Hence, a brief overview regarding the disease biomarkers, miRNAs as disease biomarkers and their role in complex disorders is given here. Various methods for calculating miRNA and disease similarities are included and the existing machine learning and network based computational approaches for detecting disease associated miRNAs are reviewed along with the benchmark dataset used. Finally, the performance matrices, validation measures and online tools used for miRNA Disease Association (MDA) predictions are also outlined.

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最新 MiRNA 疾病关联预测计算方法探索性综述

最近的证据表明，miRNAs 作为疾病生物标志物的基本作用及其在疾病进展和病理学中的作用。利用计算方法鉴定与疾病相关的 miRNA 已成为健康信息学的热门话题之一。许多生物数据库和在线工具都是为发现新型疾病相关 miRNAs 而开发的。因此，本文简要概述了疾病生物标志物、作为疾病生物标志物的 miRNA 及其在复杂疾病中的作用。此外，还介绍了计算 miRNA 与疾病相似性的各种方法，并回顾了用于检测与疾病相关的 miRNA 的现有机器学习和基于网络的计算方法以及所使用的基准数据集。最后，还概述了用于 miRNA 疾病关联（MDA）预测的性能矩阵、验证措施和在线工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.