A Review Exploring the Wound-Healing Activity of Self-Healing Hydrogels: Fabrication, Characterization, Mechanism, and Biomedical Applications

IF 2.7 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Cluster Science Pub Date : 2024-05-20 DOI:10.1007/s10876-024-02638-5

Heba-Alla H. Abd-ElSalam, Omar A. Refaeey, Khaled G. Waked, Khaled A. Elsherbiny, Aya M. Aleam, Mariam Q. Ibrahim, Marina H. Farag, AbdelRahman M. Nasef, Aliaa N. ElMeshad

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Abstract

The natural physiological response to skin injury is wound healing. However, to restore skin continuity, wound healing is a complicated process that involves the collaboration of a variety of cell types and other mediators. This process ultimately results in tissue regeneration and the restoration of skin barrier function. Hydrogels are appealing dosage forms for biomedical regenerative medicine since they are composed of 3D networks with high water content and flexible rheological features. Hydrogels that can self-heal are particularly interesting for wound treatment because they can autonomously restore their original functionalities and repair structural damage. Recently, the use of self-healing hydrogels as biomedical materials has attracted increased interest. In this review, the self-healing systems used in tissue regeneration, especially wound healing, will be explored. A focus on the fabrication methods, characterization tests, and mechanism of self-healing will be introduced, along with the biomedical applications of self-healing hydrogels loaded with conventional and therapeutic biomaterials. In addition, the differences between hydrogels and self-healing hydrogels will be discussed.

Graphical Abstract

Abstract Image

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自愈合水凝胶伤口愈合活性综述：自愈合水凝胶的制造、表征、机制和生物医学应用

皮肤损伤的自然生理反应是伤口愈合。然而，要恢复皮肤的连续性，伤口愈合是一个复杂的过程，涉及多种细胞类型和其他介质的协作。这一过程最终会导致组织再生和皮肤屏障功能的恢复。水凝胶由三维网络组成，具有高含水量和灵活的流变特性，因此是生物医学再生医学中极具吸引力的剂型。能自我修复的水凝胶尤其适用于伤口治疗，因为它们能自主恢复原有功能并修复结构损伤。最近，自愈合水凝胶作为生物医学材料的应用引起了越来越多的关注。本综述将探讨用于组织再生（尤其是伤口愈合）的自愈合系统。重点将介绍自愈合的制造方法、表征测试和机理，以及自愈合水凝胶与传统和治疗性生物材料的生物医学应用。此外，还将讨论水凝胶与自愈合水凝胶之间的区别。

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来源期刊

Journal of Cluster Science 化学-无机化学与核化学

CiteScore

6.70

自引率

0.00%

发文量

166

审稿时长

3 months

期刊介绍： The journal publishes the following types of papers: (a) original and important research; (b) authoritative comprehensive reviews or short overviews of topics of current interest; (c) brief but urgent communications on new significant research; and (d) commentaries intended to foster the exchange of innovative or provocative ideas, and to encourage dialogue, amongst researchers working in different cluster disciplines.