NFAT activation by FKBP52 promotes cancer cell proliferation by suppressing p53

IF 3.3 2区生物学 Q1 BIOLOGY

Life Science Alliance Pub Date : 2024-05-21 DOI:10.26508/lsa.202302426

Shunsuke Hanaki, M. Habara, Haruki Tomiyasu, Yuki Sato, Yosei Miki, T. Masaki, Shusaku Shibutani, M. Shimada

引用次数: 0

Abstract

FKBP52 promotes nuclear translocation of NFATc, which activates MDM2 transcription, thus suppressing p53 expression and promoting cell proliferation.

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FKBP52 激活的 NFAT 通过抑制 p53 促进癌细胞增殖

FKBP52 可促进 NFATc 的核转位，而 NFATc 可激活 MDM2 的转录，从而抑制 p53 的表达并促进细胞增殖。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life Science Alliance Agricultural and Biological Sciences-Plant Science

CiteScore

5.80

自引率

2.30%

发文量

241

审稿时长

10 weeks

期刊介绍： Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.