Evaluation of the Open Source Process Simulator DWSIM for Bioprocess Simulation

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-22 DOI:10.3311/ppch.23166

Siddhi Sreemahadevan, Krishnapriya Velusamy Sivakumar, Menjith Palanisamy

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Abstract

In the recent times, the application of process simulation software has found its way to the simulation of bioprocesses. Presently, bioprocesses are simulated and technoeconomic analysis is performed in commercially available software for such as SuperPro Designer®, Aspen Plus® etc. These softwares are not freely available and therefore, there exists a need for an open source software for the simulation of bioprocesses. Furthermore, the chemical process softwares show compatibility issues, when used for bioprocesses. More recently, an open source process simulator called DWSIM was introduced for the simulation of chemical processes. However, the applicability and compatibility of DWSIM for complex bioprocess simulation involving microbial biomass has not been reported yet. Therefore, the present study evaluates and reports the simulation results of the bioethanol production process developed by NREL (National Renewable Energy Laboratory, USA), performed in DWSIM. The simulator results were compared to those of existing commercial software, and the results showed good agreement with the literature. This suggests that DWSIM could be a promising alternative for bioprocess flowsheeting and simulation, and further technoeconomic analysis.

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评估用于生物过程模拟的开源过程模拟器 DWSIM

近来，工艺模拟软件已开始应用于生物工艺模拟。目前，生物工艺的模拟和技术经济分析都是通过商业软件进行的，如 SuperPro Designer®、Aspen Plus® 等。这些软件不能免费提供，因此需要一种开源软件来模拟生物工艺。此外，化学工艺软件在用于生物工艺时会出现兼容性问题。最近，一种名为 DWSIM 的开源过程模拟器被引入到化学过程模拟中。然而，DWSIM 在涉及微生物生物质的复杂生物过程模拟中的适用性和兼容性尚未见报道。因此，本研究评估并报告了 NREL（美国国家可再生能源实验室）开发的生物乙醇生产过程在 DWSIM 中的模拟结果。模拟结果与现有商业软件的模拟结果进行了比较，结果显示与文献资料十分吻合。这表明，DWSIM 有可能成为生物工艺流程设计和模拟以及进一步技术经济分析的理想选择。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.