System biology approaches for drug repurposing.

3区 生物学 Q2 Biochemistry, Genetics and Molecular Biology
Juveriya Israr, Shabroz Alam, Ajay Kumar
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引用次数: 0

Abstract

Drug repurposing, or drug repositioning, refers to the identification of alternative therapeutic applications for established medications that go beyond their initial indications. This strategy has becoming increasingly popular since it has the potential to significantly reduce the overall costs of drug development by around $300 million. System biology methodologies have been employed to facilitate medication repurposing, encompassing computational techniques such as signature matching and network-based strategies. These techniques utilize pre-existing drug-related data types and databases to find prospective repurposed medications that have minimal or acceptable harmful effects on patients. The primary benefit of medication repurposing in comparison to drug development lies in the fact that approved pharmaceuticals have already undergone multiple phases of clinical studies, thereby possessing well-established safety and pharmacokinetic properties. Utilizing system biology methodologies in medication repurposing offers the capacity to expedite the discovery of viable candidates for drug repurposing and offer novel perspectives for structure-based drug design.

药物再利用的系统生物学方法。
药物再利用或药物再定位指的是为已有的药物确定超出其最初适应症的替代治疗用途。这种策略越来越受欢迎,因为它有可能将药物开发的总成本大幅降低约 3 亿美元。系统生物学方法已被用于促进药物再利用,包括特征匹配和基于网络的策略等计算技术。这些技术利用已有的药物相关数据类型和数据库,找到对患者有害影响最小或可接受的潜在再利用药物。与药物开发相比,药物再利用的主要好处在于,已批准的药品已经过多个阶段的临床研究,因此具有公认的安全性和药代动力学特性。在药物再利用中采用系统生物学方法可加快发现可行的候选药物,为基于结构的药物设计提供新的视角。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.00
自引率
0.00%
发文量
110
审稿时长
4-8 weeks
期刊介绍: Progress in Molecular Biology and Translational Science (PMBTS) provides in-depth reviews on topics of exceptional scientific importance. If today you read an Article or Letter in Nature or a Research Article or Report in Science reporting findings of exceptional importance, you likely will find comprehensive coverage of that research area in a future PMBTS volume.
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