A pro-reparative bioelectronic device for controlled delivery of ions and biomolecules.

IF 3.8 3区医学 Q2 CELL BIOLOGY

Wound Repair and Regeneration Pub Date : 2024-09-01 Epub Date: 2024-05-25 DOI:10.1111/wrr.13191

Narges Asefifeyzabadi, Tiffany Nguyen, Houpu Li, Kan Zhu, Hsin-Ya Yang, Prabhat Baniya, Andrea Medina Lopez, Anthony Gallegos, Hao-Chieh Hsieh, Harika Dechiraju, Cristian Hernandez, Kaelan Schorger, Cynthia Recendez, Maryam Tebyani, John Selberg, Le Luo, Elana Muzzy, Cathleen Hsieh, Alexie Barbee, Jonathan Orozco, Moyasar A Alhamo, Michael Levin, Elham Aslankoohi, Marcella Gomez, Min Zhao, Mircea Teodorescu, Roslyn Rivkah Isseroff, Marco Rolandi

{"title":"A pro-reparative bioelectronic device for controlled delivery of ions and biomolecules.","authors":"Narges Asefifeyzabadi, Tiffany Nguyen, Houpu Li, Kan Zhu, Hsin-Ya Yang, Prabhat Baniya, Andrea Medina Lopez, Anthony Gallegos, Hao-Chieh Hsieh, Harika Dechiraju, Cristian Hernandez, Kaelan Schorger, Cynthia Recendez, Maryam Tebyani, John Selberg, Le Luo, Elana Muzzy, Cathleen Hsieh, Alexie Barbee, Jonathan Orozco, Moyasar A Alhamo, Michael Levin, Elham Aslankoohi, Marcella Gomez, Min Zhao, Mircea Teodorescu, Roslyn Rivkah Isseroff, Marco Rolandi","doi":"10.1111/wrr.13191","DOIUrl":null,"url":null,"abstract":"Wound healing is a complex physiological process that requires precise control and modulation of many parameters. Therapeutic ion and biomolecule delivery has the capability to regulate the wound healing process beneficially. However, achieving controlled delivery through a compact device with the ability to deliver multiple therapeutic species can be a challenge. Bioelectronic devices have emerged as a promising approach for therapeutic delivery. Here, we present a pro-reparative bioelectronic device designed to deliver ions and biomolecules for wound healing applications. The device incorporates ion pumps for the targeted delivery of H+ and zolmitriptan to the wound site. In vivo studies using a mouse model further validated the device's potential for modulating the wound environment via H+ delivery that decreased M1/M2 macrophage ratios. Overall, this bioelectronic ion pump demonstrates potential for accelerating wound healing via targeted and controlled delivery of therapeutic agents to wounds. Continued optimization and development of this device could not only lead to significant advancements in tissue repair and wound healing strategies but also reveal new physiological information about the dynamic wound environment.","PeriodicalId":23864,"journal":{"name":"Wound Repair and Regeneration","volume":" ","pages":"709-719"},"PeriodicalIF":3.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Wound Repair and Regeneration","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/wrr.13191","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/25 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Wound healing is a complex physiological process that requires precise control and modulation of many parameters. Therapeutic ion and biomolecule delivery has the capability to regulate the wound healing process beneficially. However, achieving controlled delivery through a compact device with the ability to deliver multiple therapeutic species can be a challenge. Bioelectronic devices have emerged as a promising approach for therapeutic delivery. Here, we present a pro-reparative bioelectronic device designed to deliver ions and biomolecules for wound healing applications. The device incorporates ion pumps for the targeted delivery of H⁺ and zolmitriptan to the wound site. In vivo studies using a mouse model further validated the device's potential for modulating the wound environment via H⁺ delivery that decreased M1/M2 macrophage ratios. Overall, this bioelectronic ion pump demonstrates potential for accelerating wound healing via targeted and controlled delivery of therapeutic agents to wounds. Continued optimization and development of this device could not only lead to significant advancements in tissue repair and wound healing strategies but also reveal new physiological information about the dynamic wound environment.

查看原文本刊更多论文

用于控制离子和生物分子输送的生物电子设备。

伤口愈合是一个复杂的生理过程，需要精确控制和调节许多参数。治疗性离子和生物分子输送能够有效调节伤口愈合过程。然而，如何通过一个小巧的装置实现可控传输，并能传输多种治疗药物，这可能是一个挑战。生物电子装置已成为一种很有前景的治疗递送方法。在这里，我们展示了一种用于输送离子和生物分子以促进伤口愈合的生物电子装置。该装置结合了离子泵，可向伤口部位定向输送 H+ 和佐米曲普坦。利用小鼠模型进行的体内研究进一步验证了该装置通过输送 H+ 调节伤口环境的潜力，从而降低了 M1/M2 巨噬细胞比率。总之，这种生物电子离子泵通过向伤口定向、可控地输送治疗药物，展示了加速伤口愈合的潜力。继续优化和开发这种装置不仅能在组织修复和伤口愈合策略方面取得重大进展，还能揭示有关动态伤口环境的新生理信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Wound Repair and Regeneration 医学-皮肤病学

CiteScore

5.90

自引率

3.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.