TLR9 gene polymorphism confers risk to Helicobacter pylori infection in Jiangsu, China and its inspiration for precision nursing car.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.3233/THC-231677

Yan Liang, Dan Wang

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引用次数: 0

Abstract

Background: The number of studies which investigate the association between TLR9 gene polymorphism and Helicobacter pylori (H.pylori) infection is low and their results are not consistent.

Objective: To get a better understanding of the association between TLR9 gene polymorphism and H.pylori infection, providing basis and risk assessment for precision nursing for hospital nurses.

Methods: A total of 630 normal physical examination subjects were collected including 240 H.pylori (+) and 390 H.pylori (-) subjects. PCR-RFLP was applied to investigate the present polymorphism. At the same time, the meta-analysis was performed between TLR9 gene polymorphism and H.pylori infection risk.

Results: Three genotypes (TT, TC, and CC) were observed for TLR9 gene rs187084 polymorphism. CC genotype and C allele were responsible for the significant associations (all P< 0.05). Meta-analysis found no significant associations were found by any genetic models (all P> 0.05).

Conclusion: TLR9 polymorphism has a crucial role in H.pylori infection risk and CC genotype confers increased risk to H.pylori infection in the Southern Chinese population. After understanding the influence of TLR9 gene polymorphism on H.pylori infection, nurses can improve the risk assessment of Helicobacter pylori infection and provide health education more personally.

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中国江苏幽门螺杆菌感染风险的TLR9基因多态性及其对精准护理车的启示。

背景：研究 TLR9 基因多态性与幽门螺旋杆菌（Helobacter pylori，H.pylori）感染关系的研究数量较少，且结果不一致：调查TLR9基因多态性与幽门螺旋杆菌（Helicobacter pylori，H.pylori）感染相关性的研究数量较少，且结果不一致：目的：进一步了解TLR9基因多态性与幽门螺杆菌感染的关系，为医院护士的精准护理提供依据和风险评估：方法：收集正常体检者共 630 例，其中幽门螺杆菌（+）240 例，幽门螺杆菌（-）390 例。应用 PCR-RFLP 技术研究了幽门螺杆菌的多态性。同时，对 TLR9 基因多态性与幽门螺杆菌感染风险进行了荟萃分析：结果：TLR9 基因 rs187084 多态性有三种基因型（TT、TC 和 CC）。CC 基因型和 C 等位基因与幽门螺杆菌感染有显著相关性（所有 P< 0.05）。Meta 分析发现，任何基因模型均未发现显著关联（所有 P> 0.05）：结论：TLR9多态性在幽门螺杆菌感染风险中具有重要作用，CC基因型会增加中国南方人群感染幽门螺杆菌的风险。在了解了TLR9基因多态性对幽门螺杆菌感染的影响后，护士可以改进幽门螺杆菌感染的风险评估，更有针对性地开展健康教育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.