Congenital Nasolacrimal Duct Obstruction - Early Diagnosis and Graded Therapeutic Approach as Key Points for Successful Management.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-24 DOI:10.1080/08820538.2024.2358328

Jens Heichel

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引用次数: 0

Abstract

Purpose: Epiphora in childhood is a frequent symptom that is typically associated with Congenital nasolacrimal duct obstruction (CNLDO). Nevertheless, inflammatory pathologies of the ocular surface as well as inside the eye, or even congenital glaucoma, must be considered in the differential diagnosis.

Methods: A comprehensive literature review concerning CNLDO was conducted. Different therapeutic steps are categorized and summarized in order to reflect the existing staged therapeutic concept.

Results: For CNLDO, a staged therapeutic concept is applicable, resulting in a cure rate of approximately 95% with only conservative or minimally invasive intervention. This concept includes five steps that encompass therapeutic interventions with increasing complexity. It includes conservative techniques, followed by probing and syringing, transcanalicular approaches without or with lacrimal intubation, and dacryocystorhinostomy which is the ultima ratio.

Conclusion: To preserve the topographic anatomy as much as possible, therapeutic recommendations enable stepwise and individualized management of children with CNLDO.

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先天性鼻泪管阻塞--早期诊断和分级治疗是成功治疗的关键。

目的：儿童期外溢是一种常见症状，通常与先天性鼻泪管阻塞（CNLDO）有关。然而，在鉴别诊断时还必须考虑眼表和眼内的炎症性病变，甚至先天性青光眼：方法：对有关 CNLDO 的文献进行了全面回顾。方法：对有关 CNLDO 的文献进行了全面回顾，对不同的治疗步骤进行了分类和总结，以反映现有的分阶段治疗概念：结果：分阶段治疗概念适用于 CNLDO，只需保守或微创干预，治愈率约为 95%。这一概念包括五个步骤，治疗干预的复杂程度不断增加。它包括保守技术、探查和注射、不插泪管或插泪管的经颅方法以及泪囊鼻腔造口术（这是最高比例）：结论：为尽可能保留地形解剖结构，治疗建议可对 CNLDO 患儿进行分步和个性化治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.