Quantitative Assessment of Intracellular Effectors and Cellular Response in RAGE Activation.

Archives of internal medicine research Pub Date : 2024-01-01 Epub Date: 2024-04-26 DOI:10.26502/aimr.0168
Vinitha Deepu, Vikrant Rai, Devendra K Agrawal
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Abstract

The review delves into the methods for the quantitative assessment of intracellular effectors and cellular response of Receptor for Advanced Glycation End products (RAGE), a vital transmembrane receptor involved in a range of physiological and pathological processes. RAGE bind to Advanced Glycation End products (AGEs) and other ligands, which in turn activate diverse downstream signaling pathways that impact cellular responses such as inflammation, oxidative stress, and immune reactions. The review article discusses the intracellular signaling pathways activated by RAGE followed by differential activation of RAGE signaling across various diseases. This will ultimately guide researchers in developing targeted and effective interventions for diseases associated with RAGE activation. Further, we have discussed how PCR, western blotting, and microscopic examination of various molecules involved in downstream signaling can be leveraged to monitor, diagnose, and explore diseases involving proteins with unique post-translational modifications. This review article underscores the pressing need for advancements in molecular approaches for disease detection and management involving RAGE.

定量评估 RAGE 激活过程中的细胞内效应因子和细胞反应。
高级糖化终产物受体(RAGE)是一种参与一系列生理和病理过程的重要跨膜受体,本综述深入探讨了对其细胞内效应物和细胞反应进行定量评估的方法。RAGE 与高级糖化终产物(AGEs)和其他配体结合,进而激活多种下游信号通路,影响炎症、氧化应激和免疫反应等细胞反应。这篇综述文章讨论了 RAGE 激活的细胞内信号通路,以及 RAGE 信号在各种疾病中的不同激活方式。这将最终指导研究人员针对与 RAGE 激活相关的疾病开发有针对性的有效干预措施。此外,我们还讨论了如何利用 PCR、Western 印迹和显微镜检查参与下游信号转导的各种分子来监测、诊断和探索涉及具有独特翻译后修饰的蛋白质的疾病。这篇综述文章强调了在涉及 RAGE 的疾病检测和管理分子方法方面取得进展的迫切需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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