Soham Dasgupta, Shreyas Arya, Sanjeev Choudhary, Sunil K Jain
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引用次数: 0
Abstract
The gastrointestinal tract (GIT) is a complex system, which changes in response to requirements of the body. GIT represents a barrier to the external environment. To achieve this, epithelial cells must renew rapidly. This renewal of epithelial cells starts in the fetal life under the influence of many GIT peptides by swallowing amniotic fluid (AF). Development and maturation of GIT is a very complex cascade that begins long before birth and continues during infancy and childhood by breast-feeding. Many factors like genetic preprogramming, local and systemic endocrine secretions and many trophic factors (TF) from swallowed AF contribute and modulate the development and growth of the GIT. GIT morphogenesis, differentiation and functional development depend on the activity of various TF in the AF. This manuscript will review the role of AF borne TF in the development of GIT.
胃肠道（GIT）是一个复杂的系统，它会随着人体的需要而变化。胃肠道是外界环境的屏障。为此，上皮细胞必须快速更新。这种上皮细胞的更新始于胎儿时期，通过吞咽羊水（AF）在许多 GIT 肽的影响下开始。胃肠道的发育和成熟是一个非常复杂的过程，早在出生前就已开始，并通过母乳喂养延续到婴儿期和儿童期。许多因素，如遗传预编程、局部和全身内分泌以及来自吞咽羊水的许多营养因子（TF），都会促进和调节胃食管的发育和生长。胃食管的形态发生、分化和功能发育取决于 AF 中各种营养因子的活性。本手稿将综述AF携带的TF在胃食管发育过程中的作用。
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