Interplay of metabolic dysfunction-associated fatty liver disease and papillary thyroid carcinoma: insights from a Chinese cohort.

IF 5.4 2区 医学 Q1 Medicine
R Xiao, Q Wang, C Ni, W Pan, W Wu, Y Cai, K Xie, J You
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引用次数: 0

Abstract

Purpose: Thyroid cancer is one of a set of extrahepatic cancers that closely linked to metabolic dysfunction-associated fatty liver disease (MAFLD). However, the connection between MAFLD and the characteristics of papillary thyroid cancer (PTC) remains unexplored.

Methods: Between Jan 2020 and Oct 2022, surgical cases of PTC patients were examined at the first Affiliated Hospital of Wenzhou Medical University. Clinical data extracted from the electronic medical system underwent a rigorous comparison between two groups, classified based on MAFLD criteria, using logistic regression analysis.

Results: In this study of 4,410 PTC patients, 18.3% had MAFLD. MAFLD emerged as a distinct risk factor for lymph node metastasis (OR = 1.230, 95% CI 1.018-1.487) in this cohort, especially in females (OR = 1.321, 95% CI 1.026-1.702) and those with BMI ≥ 23 kg/m2 (OR = 1.232, 95% CI 1.004-1.511). The presence of MAFLD was found to significantly elevate the risk of BRAF V600E mutation in both subgroups characterized by FIB-4 score ≥ 1.3 (OR = 1.968, 95% CI 1.107-3.496) and BMI < 23 kg/m2 (OR = 2.584, 95% CI 1.012-6.601). Moreover, among the subset of individuals without non-alcoholic fatty liver disease (NAFLD), it was noted that MAFLD considerably increased the likelihood of tumor multifocality (OR = 1.697, 95% CI 1.111-2.592). Nevertheless, MAFLD did not exhibit any correlation with increased tumor size, extra-thyroidal extension (ETE), or later TNM stage in PTC.

Conclusion: In this cross-sectional study, we discovered a significant association between MAFLD and increased occurrences of lymph node metastasis. Furthermore, MAFLD was linked to a higher chance of BRAF V600E mutation and the presence of multiple tumors in certain subgroups.

Abstract Image

代谢功能障碍相关性脂肪肝与甲状腺乳头状癌的相互作用:来自中国队列的启示。
目的:甲状腺癌是与代谢功能障碍相关性脂肪肝(MAFLD)密切相关的肝外癌症之一。然而,MAFLD与甲状腺乳头状癌(PTC)特征之间的联系仍未得到研究:2020年1月至2022年10月期间,温州医科大学附属第一医院对PTC患者的手术病例进行了研究。从电子医疗系统中提取临床数据,根据 MAFLD 标准,采用逻辑回归分析法对两组患者进行严格比较:在这项对 4410 名 PTC 患者进行的研究中,18.3% 的患者患有 MAFLD。在这组患者中,MAFLD是淋巴结转移的一个明显风险因素(OR = 1.230,95% CI 1.018-1.487),尤其是女性(OR = 1.321,95% CI 1.026-1.702)和体重指数≥23 kg/m2的患者(OR = 1.232,95% CI 1.004-1.511)。在FIB-4评分≥1.3(OR = 1.968,95% CI 1.107-3.496)和BMI为2(OR = 2.584,95% CI 1.012-6.601)的两个亚组中,发现存在MAFLD会显著增加BRAF V600E突变的风险。此外,在没有非酒精性脂肪肝(NAFLD)的人群中,MAFLD大大增加了肿瘤多灶性的可能性(OR = 1.697,95% CI 1.111-2.592)。然而,MAFLD与PTC的肿瘤大小增加、甲状腺外扩展(ETE)或TNM分期较晚并无任何相关性:在这项横断面研究中,我们发现MAFLD与淋巴结转移发生率增加之间存在显著关联。此外,在某些亚组中,MAFLD与BRAF V600E基因突变和多发性肿瘤的出现几率较高有关。
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来源期刊
Journal of Endocrinological Investigation
Journal of Endocrinological Investigation ENDOCRINOLOGY & METABOLISM-
CiteScore
8.10
自引率
7.40%
发文量
242
期刊介绍: The Journal of Endocrinological Investigation is a well-established, e-only endocrine journal founded 36 years ago in 1978. It is the official journal of the Italian Society of Endocrinology (SIE), established in 1964. Other Italian societies in the endocrinology and metabolism field are affiliated to the journal: Italian Society of Andrology and Sexual Medicine, Italian Society of Obesity, Italian Society of Pediatric Endocrinology and Diabetology, Clinical Endocrinologists’ Association, Thyroid Association, Endocrine Surgical Units Association, Italian Society of Pharmacology.
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