Italian Association of Hospital Cardiologists Position Paper 'Gender discrepancy: time to implement gender-based clinical management'.

IF 1.7 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

European Heart Journal Supplements Pub Date : 2024-05-16 eCollection Date: 2024-04-01 DOI:10.1093/eurheartjsupp/suae034

Fabiana Lucà, Daniela Pavan, Michele Massimo Gulizia, Maria Teresa Manes, Maurizio Giuseppe Abrignani, Francesco Antonio Benedetto, Irma Bisceglia, Silvana Brigido, Pasquale Caldarola, Raimondo Calvanese, Maria Laura Canale, Giorgio Caretta, Roberto Ceravolo, Alaide Chieffo, Cristina Chimenti, Stefano Cornara, Ada Cutolo, Stefania Angela Di Fusco, Irene Di Matteo, Concetta Di Nora, Francesco Fattirolli, Silvia Favilli, Giuseppina Maura Francese, Sandro Gelsomino, Giovanna Geraci, Simona Giubilato, Nadia Ingianni, Annamaria Iorio, Francesca Lanni, Andrea Montalto, Federico Nardi, Alessandro Navazio, Martina Nesti, Iris Parrini, Annarita Pilleri, Andrea Pozzi, Carmelo Massimiliano Rao, Carmine Riccio, Roberta Rossini, Pietro Scicchitano, Serafina Valente, Giuseppe Zuccalà, Domenico Gabrielli, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva

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引用次数: 0

Abstract

It has been well assessed that women have been widely under-represented in cardiovascular clinical trials. Moreover, a significant discrepancy in pharmacological and interventional strategies has been reported. Therefore, poor outcomes and more significant mortality have been shown in many diseases. Pharmacokinetic and pharmacodynamic differences in drug metabolism have also been described so that effectiveness could be different according to sex. However, awareness about the gender gap remains too scarce. Consequently, gender-specific guidelines are lacking, and the need for a sex-specific approach has become more evident in the last few years. This paper aims to evaluate different therapeutic approaches to managing the most common women's diseases.

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意大利医院心脏病专家协会立场文件《性别差异：是时候实施基于性别的临床管理了》。

据评估，在心血管临床试验中，女性的代表性普遍不足。此外，据报道，在药物治疗和干预策略方面也存在很大差异。因此，许多疾病的治疗效果不佳，死亡率更高。药物代谢的药代动力学和药效学差异也已得到描述，因此不同性别的药物可能会产生不同的疗效。然而，人们对性别差异的认识仍然不足。因此，缺乏针对不同性别的指导原则，而在过去几年中，针对不同性别的方法的必要性变得越来越明显。本文旨在评估管理最常见妇女疾病的不同治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Heart Journal Supplements 医学-心血管系统

CiteScore

3.00

自引率

0.00%

发文量

575

审稿时长

12 months

期刊介绍： The European Heart Journal Supplements (EHJs) is a long standing member of the ESC Journal Family that serves as a publication medium for supplemental issues of the flagship European Heart Journal. Traditionally EHJs published a broad range of articles from symposia to special issues on specific topics of interest. The Editor-in-Chief, Professor Roberto Ferrari, together with his team of eminent Associate Editors: Professor Francisco Fernández-Avilés, Professors Jeroen Bax, Michael Böhm, Frank Ruschitzka, and Thomas Lüscher from the European Heart Journal, has implemented a change of focus for the journal. This entirely refreshed version of the European Heart Journal Supplements now bears the subtitle the Heart of the Matter to give recognition to the focus the journal now has. The EHJs – the Heart of the Matter intends to offer a dedicated, scientific space for the ESC, Institutions, National and Affiliate Societies, Associations, Working Groups and Councils to disseminate their important successes globally.