Philipp F Arndt, Kati Turkowski, Michael J Cekay, Bastian Eul, Friedrich Grimminger, Rajkumar Savai
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引用次数: 0
Abstract
The tumor microenvironment (TME) plays a central role in the development of cancer. Within this complex milieu, the endothelin (ET) system plays a key role by triggering epithelial-to-mesenchymal transition, causing degradation of the extracellular matrix and modulating hypoxia response, cell proliferation, composition, and activation. These multiple effects of the ET system on cancer progression have prompted numerous preclinical studies targeting the ET system with promising results, leading to considerable optimism for subsequent clinical trials. However, these clinical trials have not lived up to the high expectations; in fact, the clinical trials have failed to demonstrate any substantiated benefit of targeting the ET system in cancer patients. This review discusses the major and recent advances of the ET system with respect to TME and comments on past and ongoing clinical trials of the ET system.
肿瘤微环境（TME）在癌症的发展中起着核心作用。在这一复杂的环境中，内皮素（ET）系统通过触发上皮细胞向间质转化、导致细胞外基质降解、调节缺氧反应、细胞增殖、组成和活化发挥着关键作用。ET 系统对癌症进展的这些多重影响促使许多以 ET 系统为靶点的临床前研究取得了可喜的成果，从而为随后的临床试验带来了相当乐观的前景。然而，这些临床试验并没有辜负人们的厚望；事实上，临床试验未能证明以 ET 系统为靶点对癌症患者有任何确凿的益处。本综述将讨论 ET 系统在治疗肿瘤和癌症方面的主要进展和最新进展，并对过去和正在进行的 ET 系统临床试验进行评论。
期刊介绍：
Translating molecular bioscience and experimental research into medical insights, Clinical Science offers multi-disciplinary coverage and clinical perspectives to advance human health.
Its international Editorial Board is charged with selecting peer-reviewed original papers of the highest scientific merit covering the broad spectrum of biomedical specialities including, although not exclusively:
Cardiovascular system
Cerebrovascular system
Gastrointestinal tract and liver
Genomic medicine
Infection and immunity
Inflammation
Oncology
Metabolism
Endocrinology and nutrition
Nephrology
Circulation
Respiratory system
Vascular biology
Molecular pathology.
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