Utility of combining multiple parameters of ¹²³I-IMP SPECT and voxel-based morphometry MRI using a multiparametric scoring system for differentiating dementia with Lewy bodies from Alzheimer's disease.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Acta radiologica Pub Date : 2024-07-01 Epub Date: 2024-05-24 DOI:10.1177/02841851241253775

Eiji Matsusue, Chie Inoue, Manabu Shimoda, Tomoya Nakamura, Shota Matsumoto, Kensuke Matsumoto, Tomohiko Tanino, Kazuhiko Nakamura, Shinya Fujii

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引用次数: 0

Abstract

Background: Brain magnetic resonance imaging voxel-based morphometry (VBM) and perfusion single-photon emission computed tomography (SPECT) are useful for differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD).

Purpose: To determine whether combining multiple parameters of VBM and SPECT using a multiparametric scoring system (MSS) improves diagnostic accuracy in differentiating DLB from AD.

Material and methods: In total, 23 patients with DLB and 57 patients with AD underwent imaging using a voxel-based specific regional analysis system for AD (VSRAD), an easy Z-score imaging system, and a Z-Graph using three-dimensional stereotactic surface projection. The cutoff values were determined using the receiver operating characteristic curve to differentiate DLB from AD for all parameters. Patients were scored 1 (DLB) or 0 (AD) for each statistically significant parameter, according to a threshold. The total score was determined for each case to obtain a cutoff value for the MSS.

Results: The mean Z-scores in the medial temporal lobes using the VSRAD were significantly lower in patients with DLB than in those with AD. Each Z-score of the summed Z-scores in all four segmented regions of the occipital lobes using the Z-Graph was significantly higher in patients with DLB than in those with AD. Among the five parameters, the highest accuracy was 80% for the Z-score of the summed Z-scores in the left medial occipital lobe. For the MSS, a cutoff value of four improved the diagnostic accuracy to 82%.

Conclusion: MSS was more accurate than any single parameter of VBM or SPECT in differentiating DLB from AD.

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利用多参数评分系统结合 123I-IMP SPECT 和基于体素的形态测量 MRI 的多个参数，区分路易体痴呆和阿尔茨海默病的实用性。

背景：目的：确定使用多参数评分系统（MSS）结合VBM和SPECT的多个参数是否能提高区分DLB和AD的诊断准确性：共有23名DLB患者和57名AD患者使用基于体素的AD特定区域分析系统（VSRAD）、简易Z-score成像系统和使用三维立体定向表面投影的Z-Graph进行了成像。利用接收者操作特征曲线确定了所有参数的截止值，以区分 DLB 和 AD。根据临界值，患者的每项有统计学意义的参数都被记为 1 分（DLB）或 0 分（AD）。确定每个病例的总分，以获得 MSS 的临界值：结果：使用 VSRAD 测量的颞叶内侧平均 Z 值在 DLB 患者中明显低于 AD 患者。使用Z-Graph得出的枕叶所有四个分割区域的Z-分数总和中，DLB患者的每个Z-分数都明显高于AD患者。在五个参数中，左侧枕叶内侧Z分数总和的准确率最高，达到80%。就MSS而言，以4为临界值可将诊断准确率提高到82%：结论：在区分DLB和AD方面，MSS比VBM或SPECT的任何单一参数都更准确。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta radiologica 医学-核医学

CiteScore

2.70

自引率

0.00%

发文量

170

审稿时长

3-8 weeks

期刊介绍： Acta Radiologica publishes articles on all aspects of radiology, from clinical radiology to experimental work. It is known for articles based on experimental work and contrast media research, giving priority to scientific original papers. The distinguished international editorial board also invite review articles, short communications and technical and instrumental notes.

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