Characteristic deviations of the optic disc and macula in optic nerve hypoplasia based on OCT

IF 3 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2024-05-23 DOI:10.1111/aos.16722

Athanasia Skriapa-Manta, Abinaya Priya Venkataraman, Monica Olsson, Maria Nilsson, Kristina Teär Fahnehjelm

{"title":"Characteristic deviations of the optic disc and macula in optic nerve hypoplasia based on OCT","authors":"Athanasia Skriapa-Manta, Abinaya Priya Venkataraman, Monica Olsson, Maria Nilsson, Kristina Teär Fahnehjelm","doi":"10.1111/aos.16722","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Purpose</h3>\n \n <p>The purpose of this study was to evaluate the optic disc and macula in a large cohort of patients with different severity of optic nerve hypoplasia (ONH) using high-resolution spectral domain optical coherence tomography (SD-OCT).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In total, 36 patients (52 ONH eyes and 17 fellow eyes in unilateral cases) and 45 healthy right eyes from 45 controls were evaluated. All patients underwent an examination to confirm the diagnosis. SD-OCT images of the disc and macula were obtained and analysed both quantitatively and qualitatively.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>OCT in ONH eyes demonstrated a shorter disc diameter (1061 ± 375 μm vs. 1751 ± 221 μm, <i>p</i> < 0.001), shallower mean cup depth (427 ± 171 μm vs. 551 ± 152 μm, <i>p</i> = 0.01), thinner ganglion cell complex (GCC) perifoveally (47.3 ± 13.0 μm, 60.8 ± 6.0 μm, <i>p</i> < 0.001) and reduced foveal depth (61 ± 36 μm, 119 ± 19 μm, <i>p</i> < 0.001) compared to control eyes. Qualitative analysis showed that 1/3rd of ONH eyes lacked signs of an optic cup, and 2/3rd had reduced or no sign of a foveal pit. Fellow eyes had shorter disc diameter (1446 ± 404 μm vs. 1751 ± 221 μm, <i>p</i> = 0.004) and reduced foveal depth (93 ± 27 μm vs. 119 ± 19 μm, <i>p</i> < 0.001) but similar GCC thickness (60.8 ± 7.1 μm vs. 60.8 ± 6.0 μm, <i>p</i> = 0.738) compared to controls. Disc diameter showed the best correlation with visual acuity in ONH eyes (<i>ρ</i> = 0.517, <i>p</i> < 0.001).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>ONH eyes have reduced GCC thickness and reduced or no foveal pit. Fellow eyes in presumed unilateral cases have a smaller disc diameter and reduced foveal depth compared to controls, suggesting the possibility of subclinical/mild disease. However, GCC thickness was normal. The correlation between structure and visual function is not always straightforward.</p>\n </section>\n </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"102 8","pages":"922-930"},"PeriodicalIF":3.0000,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.16722","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Ophthalmologica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/aos.16722","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

The purpose of this study was to evaluate the optic disc and macula in a large cohort of patients with different severity of optic nerve hypoplasia (ONH) using high-resolution spectral domain optical coherence tomography (SD-OCT).

Methods

In total, 36 patients (52 ONH eyes and 17 fellow eyes in unilateral cases) and 45 healthy right eyes from 45 controls were evaluated. All patients underwent an examination to confirm the diagnosis. SD-OCT images of the disc and macula were obtained and analysed both quantitatively and qualitatively.

Results

OCT in ONH eyes demonstrated a shorter disc diameter (1061 ± 375 μm vs. 1751 ± 221 μm, p < 0.001), shallower mean cup depth (427 ± 171 μm vs. 551 ± 152 μm, p = 0.01), thinner ganglion cell complex (GCC) perifoveally (47.3 ± 13.0 μm, 60.8 ± 6.0 μm, p < 0.001) and reduced foveal depth (61 ± 36 μm, 119 ± 19 μm, p < 0.001) compared to control eyes. Qualitative analysis showed that 1/3rd of ONH eyes lacked signs of an optic cup, and 2/3rd had reduced or no sign of a foveal pit. Fellow eyes had shorter disc diameter (1446 ± 404 μm vs. 1751 ± 221 μm, p = 0.004) and reduced foveal depth (93 ± 27 μm vs. 119 ± 19 μm, p < 0.001) but similar GCC thickness (60.8 ± 7.1 μm vs. 60.8 ± 6.0 μm, p = 0.738) compared to controls. Disc diameter showed the best correlation with visual acuity in ONH eyes (ρ = 0.517, p < 0.001).

Conclusion

ONH eyes have reduced GCC thickness and reduced or no foveal pit. Fellow eyes in presumed unilateral cases have a smaller disc diameter and reduced foveal depth compared to controls, suggesting the possibility of subclinical/mild disease. However, GCC thickness was normal. The correlation between structure and visual function is not always straightforward.

Abstract Image

查看原文本刊更多论文

基于 OCT 的视神经发育不全患者视盘和黄斑的特征性偏差。

目的：本研究的目的是使用高分辨率光谱域光学相干断层扫描（SD-OCT）评估一大批不同严重程度的视神经发育不全（ONH）患者的视盘和黄斑：共评估了 36 名患者（52 名 ONH 患者和 17 名单侧病例的同侧患者）和 45 名对照组的 45 名健康右眼。所有患者都接受了确诊检查。获得了视盘和黄斑的 SD-OCT 图像，并进行了定量和定性分析：结果：ONH 眼的 OCT 显示视盘直径更短（1061 ± 375 μm vs. 1751 ± 221 μm，p 结论：ONH 眼的 GCC 厚度更小：ONH 眼的 GCC 厚度减小，眼窝凹陷减小或没有眼窝凹陷。与对照组相比，推测为单侧病例的同侧眼的眼盘直径较小，眼窝深度减小，这表明可能存在亚临床/轻度疾病。但 GCC 厚度正常。视网膜结构与视觉功能之间的相关性并非总是那么简单。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.