Hepatitis B Virus DNA and RNA Persist in Liver After Serologic Recovery in Persons With Hepatitis C Virus.

IF 5 2区医学 Q2 IMMUNOLOGY

Journal of Infectious Diseases Pub Date : 2024-12-16 DOI:10.1093/infdis/jiae248

Tanner Grudda, David L Thomas, Gregory D Kirk, Shruti H Mehta, Jacquie Astemborski, Georg M Lauer, Ashwin Balagopal, Chloe L Thio

引用次数: 0

Abstract

After recovery from a hepatitis B virus (HBV) infection, reactivation can occur with immunosuppression; thus, it is assumed that replication competent HBV persists in the liver. We sought to detect persistent HBV from 13 people with spontaneous recovery. We quantified HBV DNA and RNA in core liver biopsy specimens (median, 1.72 × 106 cells) from persons who inject drugs. Of 13 biopsy specimens, 8 (61%) had evidence of HBV DNA or RNA and 5 (38%) had both HBV DNA and RNA. Messenger RNAs were derived from covalently closed circular DNA and integrated HBV DNA. Here, we show prevalent HBV DNA and RNA despite clinical recovery in persons who inject drugs.

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丙型肝炎病毒感染者血清学恢复后，肝脏中仍存在乙型肝炎病毒 DNA 和 RNA。

乙型肝炎病毒（HBV）感染痊愈后，可能会在免疫抑制的情况下重新活化；因此，人们假定肝脏中存在具有复制能力的 HBV。我们试图从 13 名自发康复者中检测出持续存在的 HBV。我们对注射吸毒者（PWID）的核心肝活检组织（中位数为 1.72x106 个细胞）中的 HBV DNA 和 RNA 进行了量化。在 13 例活检中，8 例（61%）有证据表明存在 HBV DNA 或 RNA，5 例（38%）同时存在 HBV DNA 和 RNA。在此，我们显示，尽管吸毒者临床康复，但仍普遍存在 HBV DNA 和 RNA。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infectious Diseases 医学-传染病学

CiteScore

13.50

自引率

3.10%

发文量

449

审稿时长

2-4 weeks

期刊介绍： Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.