The correlation between intestinal colonization and infection of carbapenem-resistant Klebsiella pneumoniae: A systematic review

IF 3.7 3区 医学 Q2 INFECTIOUS DISEASES
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引用次数: 0

Abstract

As a widely spread Gram-negative bacteria, Klebsiella pneumoniae (KP) mainly causes acquired infections in hospitals, such as lung infections, urinary tract infections, and bloodstream infections. In recent years, the number of multidrug-resistant KP strains has increased dramatically, posing a great threat to human health. Carbapenem-resistant KP (CRKP) can be colonized in human body, especially in gastrointestinal tract, and some colonized patients can be infected during hospitalization, among which invasive operation, underlying disease, admission to intensive care unit, antibiotic use, severity of the primary disease, advanced age, operation, coma, and renal failure are common risk factors for secondary infection. Active screening and preventive measures can effectively prevent the occurrence of CRKP infection. Based on the epidemiological status, this study aims to discuss the correlation between colonization and secondary infection induced by CRKP and risk factors for their happening and provide some reference for nosocomial infection prevention and control.

耐碳青霉烯类肺炎克雷伯菌肠道定植与感染之间的相关性:系统回顾。
作为一种广泛传播的革兰氏阴性菌,肺炎克雷伯菌主要引起医院中的获得性感染,如肺部感染、尿路感染、血流感染等。近年来,对多种药物产生耐药性的肺炎克雷伯菌株数量急剧增加,对人类健康构成了巨大威胁。耐碳青霉烯类肺炎克雷伯菌(CRKP)可定植于人体内,尤其是胃肠道,部分定植患者可在住院期间发生感染,其中侵入性操作、基础疾病、入住重症监护室、抗生素使用、原发病严重程度、高龄、手术、昏迷和肾功能衰竭是继发感染的常见危险因素。积极的筛查和预防措施可以有效预防 CRKP 感染的发生。基于流行病学现状,本研究旨在探讨耐碳青霉烯类肺炎克雷伯菌定植与继发感染的相关性及其发生的危险因素,为预防和控制院内感染提供一些参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of global antimicrobial resistance
Journal of global antimicrobial resistance INFECTIOUS DISEASES-PHARMACOLOGY & PHARMACY
CiteScore
8.70
自引率
2.20%
发文量
285
审稿时长
34 weeks
期刊介绍: The Journal of Global Antimicrobial Resistance (JGAR) is a quarterly online journal run by an international Editorial Board that focuses on the global spread of antibiotic-resistant microbes. JGAR is a dedicated journal for all professionals working in research, health care, the environment and animal infection control, aiming to track the resistance threat worldwide and provides a single voice devoted to antimicrobial resistance (AMR). Featuring peer-reviewed and up to date research articles, reviews, short notes and hot topics JGAR covers the key topics related to antibacterial, antiviral, antifungal and antiparasitic resistance.
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