Sertoli cell lysosomal dysfunction drives age-related testicular degeneration

IF 3.7 3区医学 Q2 CHEMISTRY, MEDICINAL

Chemical Research in Toxicology Pub Date : 2024-05-22 DOI:10.1038/s41574-024-01001-y

Olivia Tysoe

引用次数: 0

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溶质细胞溶酶体功能障碍导致与年龄有关的睾丸退化

晚发型性腺功能减退症（LOH）是一种与年龄有关的疾病，影响着 2-6% 的 40 岁男性。LOH是睾丸产生的睾酮减少的结果，可导致疲劳、性功能障碍以及对代谢性和退行性疾病的易感性增加。对来自两名健康年轻供体（SCY）和两名LOH患者（SCLOH）的原代Sertoli细胞系进行测序后发现，与SCY相比，SCLOH中溶酶体酸化基因下调，用pH敏感染料成像证实，SCLOH的溶酶体酸度严重不足。具有这些缺陷的 Sertoli 细胞被命名为 phago/auto-lysosomal dysregulated (PALD) Sertoli 细胞。"周说："这项分析表明，Sertoli细胞溶酶体酸化异常导致脂滴积累和促炎因子分泌，是睾丸老化的一个关键特征。

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来源期刊

Chemical Research in Toxicology 医学-毒理学

CiteScore

7.90

自引率

7.30%

发文量

215

审稿时长

3.5 months

期刊介绍： Chemical Research in Toxicology publishes Articles, Rapid Reports, Chemical Profiles, Reviews, Perspectives, Letters to the Editor, and ToxWatch on a wide range of topics in Toxicology that inform a chemical and molecular understanding and capacity to predict biological outcomes on the basis of structures and processes. The overarching goal of activities reported in the Journal are to provide knowledge and innovative approaches needed to promote intelligent solutions for human safety and ecosystem preservation. The journal emphasizes insight concerning mechanisms of toxicity over phenomenological observations. It upholds rigorous chemical, physical and mathematical standards for characterization and application of modern techniques.