Grouping strategies for assessing and managing persistent and mobile substances

IF 6 3区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Parviel Chirsir, Emma H. Palm, Sivani Baskaran, Emma L. Schymanski, Zhanyun Wang, Raoul Wolf, Sarah E. Hale, Hans Peter H. Arp
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引用次数: 0

Abstract

Background

Persistent, mobile and toxic (PMT), or very persistent and very mobile (vPvM) substances are a wide class of chemicals that are recalcitrant to degradation, easily transported, and potentially harmful to humans and the environment. Due to their persistence and mobility, these substances are often widespread in the environment once emitted, particularly in water resources, causing increased challenges during water treatment processes. Some PMT/vPvM substances such as GenX and perfluorobutane sulfonic acid have been identified as substances of very high concern (SVHCs) under the European Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) regulation. With hundreds to thousands of potential PMT/vPvM substances yet to be assessed and managed, effective and efficient approaches that avoid a case-by-case assessment and prevent regrettable substitution are necessary to achieve the European Union's zero-pollution goal for a non-toxic environment by 2050.

Main

Substance grouping has helped global regulation of some highly hazardous chemicals, e.g., through the Montreal Protocol and the Stockholm Convention. This article explores the potential of grouping strategies for identifying, assessing and managing PMT/vPvM substances. The aim is to facilitate early identification of lesser-known or new substances that potentially meet PMT/vPvM criteria, prompt additional testing, avoid regrettable use or substitution, and integrate into existing risk management strategies. Thus, this article provides an overview of PMT/vPvM substances and reviews the definition of PMT/vPvM criteria and various lists of PMT/vPvM substances available. It covers the current definition of groups, compares the use of substance grouping for hazard assessment and regulation, and discusses the advantages and disadvantages of grouping substances for regulation. The article then explores strategies for grouping PMT/vPvM substances, including read-across, structural similarity and commonly retained moieties, as well as the potential application of these strategies using cheminformatics to predict P, M and T properties for selected examples.

Conclusions

Effective substance grouping can accelerate the assessment and management of PMT/vPvM substances, especially for substances that lack information. Advances to read-across methods and cheminformatics tools are needed to support efficient and effective chemical management, preventing broad entry of hazardous chemicals into the global market and favouring safer and more sustainable alternatives.

Abstract Image

评估和管理持久性和流动性物质的分组战略
背景持久性、流动性和毒性(PMT)或极持久性和极流动性(vPvM)物质是一类广泛的化学品,它们不易降解、易于迁移,并可能对人类和环境造成危害。由于其持久性和流动性,这些物质一旦排放,通常会在环境中广泛存在,尤其是在水资源中,从而给水处理过程带来更多挑战。根据欧洲化学品注册、评估、许可和限制(REACH)法规,一些 PMT/vPvM 物质,如 GenX 和全氟丁烷磺酸,已被确定为高度关注物质(SVHC)。有成百上千种潜在的 PMT/vPvM 物质尚待评估和管理,要实现欧盟到 2050 年实现无毒环境的零污染目标,就必须采取切实有效的方法,避免逐个评估,防止令人遗憾的替代品。本文探讨了分组策略在识别、评估和管理 PMT/vPvM 物质方面的潜力。其目的是促进及早识别可能符合 PMT/vPvM 标准的鲜为人知的物质或新物质,提示额外的测试,避免令人遗憾的使用或替代,并将其纳入现有的风险管理策略。因此,本文概述了 PMT/vPvM 物质,回顾了 PMT/vPvM 标准的定义和现有的各种 PMT/vPvM 物质清单。文章介绍了目前的分组定义,比较了在危害评估和监管中使用物质分组的情况,并讨论了在监管中对物质进行分组的利弊。然后,文章探讨了对 PMT/vPvM 物质进行分组的策略,包括交叉阅读法、结构相似性和常见保留分子,以及利用化学信息学预测选定实例的 P、M 和 T 特性的这些策略的潜在应用。要支持高效和有效的化学品管理,防止危险化学品广泛进入全球市场,并支持更安全和更可持续的替代品,就需要在解读方法和化学信息学工具方面取得进展。
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来源期刊
Environmental Sciences Europe
Environmental Sciences Europe Environmental Science-Pollution
CiteScore
11.20
自引率
1.70%
发文量
110
审稿时长
13 weeks
期刊介绍: ESEU is an international journal, focusing primarily on Europe, with a broad scope covering all aspects of environmental sciences, including the main topic regulation. ESEU will discuss the entanglement between environmental sciences and regulation because, in recent years, there have been misunderstandings and even disagreement between stakeholders in these two areas. ESEU will help to improve the comprehension of issues between environmental sciences and regulation. ESEU will be an outlet from the German-speaking (DACH) countries to Europe and an inlet from Europe to the DACH countries regarding environmental sciences and regulation. Moreover, ESEU will facilitate the exchange of ideas and interaction between Europe and the DACH countries regarding environmental regulatory issues. Although Europe is at the center of ESEU, the journal will not exclude the rest of the world, because regulatory issues pertaining to environmental sciences can be fully seen only from a global perspective.
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